User:Becky Kusko

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20.109 Fall 2007

Name

Becky Kusko

Course

20

Year of Graduation

2009

Email

rkusko AT mit DOT edu

Hometown

Hopewell Junction, NY

Residence

Burton-Conner, Conner 4

Subjects this Term

7.03
20.320
21F.712
20.109
UROP(credit)

Research

Current Project:


Research Interests:

  • Base Excision Repair
  • ATM, ATR, DNApk(cs)
  • MMS, Me-Lex

Research Proposal Idea: Cancerphilic bateria

It has long been known that bacteria use external signals to decide when to invade cells, and that bacteria can release proteins into the cells they invade. Using genetic engineering and synthetic biology, these two functions of bacteria could be used as a therapy for cancer. Many cancers are known to have heavily overexpressed or mutant surface proteins. Bacteria could be engineered to only recognize cells with surface proteins indicative of cancer. Moreover, the bacteria could be further mutated to release a cytotoxic agent upon entering the cell, or cause lysis/apoptosis.

Reference: Anderson, J. C., Clarke, E. J., Arkin, A. P., Voigt, C. A. “Environmentally controlled invasion of cancer cells by engineered bacteria” J. Mol Biol., 355(4), 619-27, 2005.

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