User:Andrew W Long/Notebook/Synthesis of Lipid Modulators/2015/09/21
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Reaction of 5-(methylthio)-1,3,4-thiadiazole-2-thiol & 2-chloro-3-nitropyridinePART 1: Relevant Compounds 5-(methylthio)-1,3,4-thiadiazole-2-thiol (comp1) 2-chloro-3-nitropyridine (comp2) Desired product PART 2: Prelab Calculations 5-(methylthio)-1,3,4-thiadiazole-2-thiol (comp1) [math]\displaystyle{ \frac{300mgComp1}{1}|\frac{1g}{1000mg}|\frac{1mol}{164.27g}=0.00183molComp1 }[/math] Benzene [math]\displaystyle{ \frac{0.0143mmol}{24ml}|\frac{0.00183mol}{Xml}=3.07mlBenzene }[/math] Dimethylformamide (DMF) Same as benzene (equivolume). 3.07ml DMF 2-chloro-3-nitropyridine (comp2) Equimolar with comp1: [math]\displaystyle{ \frac{Xg}{1}|\frac{1mol}{158.54g}=0.00183mol =\gt Xg = 0.290g = 290mgComp2 }[/math] PART 3: Procedure
PART 4: The Results The positive spectra from the gas chromatography mass spectrometer (GC-MS) The negative spectra from the gas chromatography mass spectrometer (GC-MS) As previously stated, neither of the spectra showed the clear presence of fragment peaks for the desired product of the synthesis. |