Recent research and review papers published, accepted for publication, under review or in preparation.
Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis. B.S. Moorthy, S. Schultz, S. Kim and E.M. Topp. Molecular Pharmaceutics, in preparation. Submitted to AbbVie for internal review, April 23, 2013.
Microarrays and mirconeedle arrays for delivery of peptides, proteins, vaccines and other applications. S. Chandrasekhar, L.K. Iyer, J.P. Panchal, E.M. Topp, J.B. Cannon and V.V. Ranade, Expert Opinion in Drug Delivery, submitted May 30, 2012. Accepted for publication April 15, 2013.
Solid-state hydrogen deuterium exchange. Xxx, xxx, xxx and E.M. Topp, in Hydrogen-Deuterium Exchange Mass Spectrometry: Fundamentals, Techniques and Applications, D. Weis (ed.), Wiley, New York, in preparation.
Effect of deamidation on the in vivo fate of monoclonal antibodies. S. Chandrasekhar, B.S. Moorthy, B. Xie and E.M. Topp, in Biobetters: Protein Engineering to Approach the Curative, A. Rosenberg and B. Demeule (eds.), Advances in Pharmaceutical Sciences series, Academic Press, New York, invited.
Commentary: Current perspectives on the aggregation of protein drugs. E. M. Topp, AAPS Journal, submitted December 5, 2012.
Approaches to pharmaceutical product design. B.C. Roughton, K.V. Camarada and E.M. Topp, in Ullman’s Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH & Co., Mannheim, Germany, 2012. Pp. xx-xx. DOI: 10.1002/14356007.o22_o08; online posting April 15, 2012.
Optimizing protein-excipient interactions for the development of aggregation-reducing lyophilized formulations. B.C. Roughton, A.I. Pokphanh, E.M. Topp and K.V. Camarda, Proceedings of the 11th International Symposium on Process Systems Engineering, I. a Karimi and R. Srinivasan (eds.), Elsevier, Oxford, UK, 2012. pp. 1351-1355.
Probing protein conformation in lyophilized powders by hydrogen/deuterium exchange: Deuterium uptake kinetics in lyophilized myoglobin powders. A. Sophocleous and E.M. Topp. Molecular Pharmaceutics. Invited manuscript for special issue, “Advances in Biophysical and Bioanalytical Protein Characterization”. Submitted August 17, 2011. Reviewers’ comments received November 16, 2011.
Localized effects of hydration on lyophilized myoglobin by hydrogen/deuterium exchange mass spectrometry. A.M. Sophocleous, J. Zhang and E.M. Topp. Submitted to Biophysical Journal, June 24, 2011. Reviewers’ comments received August 15, 2011. Revised version submitted October 29, 2011.
Proteins and peptides: Physical and chemical stability. Andreas Sophocleous, Jun Zhang, Lavanya Iyer, Saradha Chandra Sekhar and Elizabeth M. Topp. Encyclopedia of Pharmaceutical Science and Technology, 4th ed., James Swarbrick, D.Sc., Ph.D., Editor. Informa Healthcare, New York, NY. Submitted April 26, 2011.