PHYC500/2007:Supporting material

Spring 2007 Physics 500 and Physics 400

Home Schedule People Interactions Supporting Material Help

Dr. Parsegian talk, April 6

I believe this is the Linus Pauling paper that Dr. Parsegian recommended reading (PMID 14816373): You can get the article here:"The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain."
- While searching for the alpha helix paper, I also ran across this Pauling paper from 15 years earlier (1956, PMID 16577722). I actually found it interesting to read, in the context of 1936, very readable line of reasoning about what is happening with denatured proteins. You can get the article here: "On the Structure of Native, Denatured, and Coagulated Proteins."
I think he also recommended a 1938 paper by I. Langmuir in J. Chem Phys...however, I cannot locate this reference.

Kevin posted on the course website two questions and two answers.

Some background material:

A wonderful website with a tremendous amount of information about microscopy including fluorescence microscopy:

A link to our Optics Express paper demonstrating super-resolved blinking quantum dots:

Thanks to those who came for my talk! Here's my slides if you want to take a look: Media:Phys500_pikaart.pdf

If you are interested in ways to look at protein structures, go to the PDB website. PDB is the "Protein Data Bank," i.e. the repository for just about all known biomolecule structures. You can find structures in the "Site Search" window either by entering the unique PDB ID if you know it for the structure you're looking for - for example, 2GAT is the structure of the Gata-DNA complex - or by name. Entering "2GAT" will pull up the structure with a little cartoon of it on the righthand side. Underneath the cartoon (where it says "Display Options") you can open the structure in various viewers. The simpler ones open right up as Java applications, so KiNG (the most esthetically enjoyable of them in my opinion), Jmol (which looks a lot like Chime), and Webmol (Rasmol-esque). The Swiss-pdb viewer is a lot like the PyMol viewer I showed (available here); that's a plugin you install on your machine. In the not-for-the-faint-of-heart category, the big daddy of them all is the program VMD (Visual Molecular Dynamics) from UIUC, which is a great way to tie into computational chemistry approaches.
- This also looks like it may be very useful for rendering: http://bioserv.rpbs.jussieu.fr/~autin/help/PMGtuto.html

Here is a 10 MB file of his slides: Media:070117 PHYC 500 Koch Presentation.ppt (It's a powerpoint file, not MS Word...you can find the file on the course website too.) Videos from the talk (I didn't show these, so they probably won't make sense, but putting on because slides link to them):
No Force Epi
700 fN Epi
Evanescent Wave Detection, Cycling force off / on