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20.310 Term Paper

Sickle Cell Anemia

Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology.

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DNApol processivity as a function of tension in the strand of template DNA

Processivity

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DNA Stretching

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Miscellaneous

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