Koch HTS Facility:Libraries
Publicly Available Compound Collections
BML-2832 Kinase Inhibitor Library
80 compounds. Includes inhibitors of these important kinases: Insulin/IGF Receptors, PI 3-Kinase, CaM Kinase II, JAK, PKA, CDK, JNK, PKC, CKI II, MAPK, RAF, EGFR, MEK, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR and many more.
BML-2840 ICCB Known Bioactives
472 compounds. Includes compounds that affect most cellular processes and drug targer classes, including: GPCR ligands, Second messenger modulators, Nuclear receptor ligands, Actin and tubulin modulators, Kinase inhibitors, Protease inhibitors, Ion channel blockers, Gene regulation agents, Lipid biosynthesis inhibitors, Phosphodiesterase inhibitors, and many other classes.
BML-2843 FDA-Approved Library
800 compounds that can be used for diverse drug discovery in the fields of cardiology, neuropsychiatry, immunology, oncology and more. Drug repositioning or repurposing can be an important part of any drug discovery program. Being FDA approved and in use in the clinics, all of the compounds in Screen-Well™ FDA v. 2.0 Approved Drug Library have known and well-characterized bioactivity, safety and bioavailability - properties which could dramatically accelerate drug development and optimization. The library also avoids irrelevant compounds found in similar libraries, such as herbicides, insecticides, sunscreen agents, and cytotoxic agents. This set provides one of the richest sources of bioactives and offers the greatest degree of drug-likeness available.
BML-2865 Natural Products Library
502 compounds including compounds from the following classes of products: Terpenoids, Peptolides, Flavones, Coumarins, Alkaloids, Macrolides, Isoflavones, Synthetic derivates and many more.
Selleck Cambridge Cancer Compound Library
392 hand-picked anti-cancer compounds target known proteins or nodes involved in cancers
Boston University’s CMLD deck
BU’s CMLD (Chemical Methodology and Library Development) compound deck contains novel chemotypes that uniquely probe three-dimensional space by employing stereochemical and positional variation within the molecular framework as diversity elements in library design. Compound library: ~2800 compounds. A subset of published structures is available for perusal.
Collaborators: Lauren Brown, PhD and John Porco, PhD
A collection of ~50,000 compounds that have been computationally selected to meet certain criteria related to pharmacologic properties while exploring a diversity of stereochemical parameters and structural parameters. Stock concentration: 10 mM.
Stanley Center HDAC inhibitors
HDAC inhibitor tool kit designed by the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard.