Building blocks

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Inventory of different kind of building blocks required.

Adaptors

If we want our system to be as modular as possible we'll have to use very efficient adaptor domains. For example, we can couple a unique "writer domain" to multiple targeting domains.

Proteins:

  • Leucine zippers
  • PDZ domains

(note: check for Kd etc...)


Targeting domains

We will probably have to target enzymes to specific DNA sites for example or proteins to specific localizations.

  • DNA targetting domain

zinc-finger other DNA binding domains

  • Localization domains

Nuclear localization signals

Nuclear export sequences

Membrane targeting

mitochondrial targeting

Endoplasmic reticulum

Secretion

Nuclear membrane

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