AbstractWe are constructing a chain-reactive molecule-releasing system in this project. In living organisms, signal transduction is widely used in many situations. Here we purpose a signal transduction-like system based on DNA nanotechnplogy.
In our project, Key DNAs and payload molecules are encapsulated in a liposome. The Key DNA is specially designed to collapse the liposome when some initiation stimulus is applied. Once one of the liposomes collapsed, the Key DNAs are released from the liposome and that break other liposomes in chain-reactive fashion.
This mechanism of “chain-reactive burst” enables us to release a large amount of payload molecules all at once, driven by a faint key signal. We believe this system offers a fundamental technique of signal transduction/amplification of various kinds of chemical or physical signals, applicable to Drug Delivery System, molecular computers and so on.