Biomod/2012/UTokyo/UT-Komaba/Home-Test

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DNA tablet

Welcome to our wiki page!

Our goal is to make the smallest tablet computer by DNA!

Introduction

The most significant characteristic of DNA is stability. Previously, many DNA nano structures were designed to apply the stability. Although the stability is the merit of DNA, it can also be demerit.

Let's think about the situation that you put the nano structure into human body. There is something effective to human body inside the structure. The structure is designed so strongly that it cannot be destroyed in human body. However, the structure should be also designed to collapse at the certain place for the purpose of affecting the body. Therefore, it is necessary for the DNA nano structure to have the two opposite characteristics; stability and variability.

A lot of research on DNA nano structure with stability and variability has been conducted recently. UT-Komaba team tries to show the possibility of the characteristics by designing the DNA tablet.

Abstract

Inspired by tablet computers, we propose a DNA origami (tablet) that can display alternative pictures or show a short molecular movie. Our approach combines DNA nanotechnology and DNA dynamic circuits. To demonstrate the unveiling of different images, we created a DNA origami with two latent designs and connected it with a dynamic network having two stables states. This bistability ensures that only one of the two images is displayed at a time, and no intermediate erroneous displays are produced.

The user can browse his library of images, by introducing a small amount of an image-specific tag sequence to switch the bistable system. The size of the library, currently two, could be extended by using a n-stable system to show n different pictures. Images on the DNA-tablet are created by hybridization with the state-dependent products of the bistable network and can be observed by AFM. The DNA tablet can also be modified to cycle through several pictures autonomously, by adapting it to a DNA oscillator.

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