Bioinformatics:Notebook/DNA Microarray Research

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Project Description/Abstract

DNA microarray analysis is a recently developed technique, which allows study and classification of genes. Using this technology, it allows compression of thousands of DNA nucleotide sequences on a single microscope glass. The substrate of a microarray consists of a piece of glass, or sometimes a silicon chip, similar to a microscope slide. Onto this substrate thousands of patches of single-strandedDNAare fixed which are called probes. A typical microarray is a 2 × 4 cm membrane or a microscope glass slide with a probe diameter of 75– 100 μm and a 150 μm distance between probes. The location and sequence of each patch ofDNAare known.

The main challenges in DNA microarray is to analysis of the spots in the obtained image. The existing software packages vary depending on the manufacturer of the microarray chip as well as the specific application of the chip. The complexity for the analysis could range from several minutes to hours, depending on the required image quality and the proficiency of the operators. Aim of our project is to eliminate the issues in analysis of DNA microarray with an improved algorithm and model.

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  • Example: This project is currently on hold until further notice.


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