The BioMicro Center offers formal training programs for commercial software as well as office hours during which Center staff help with data analysis. The Center also offers a BioMicroCenter:microarray club every two weeks with expert speakers from various institutes and industries. In addition to the microarray club, the Center sponsors an annual conference with a focus on computational and systems biology.
The BioMicro Center provides information to users regarding current normalization strategies used in the field. References that our users have found useful are listed below.
Two color array normalization
(Sandrine Dudoit, Yee Hwa Yang, Matthew J. Callow, and Terence P. Speed) (Image:Differentially expressed genes in replicated cDNA microarray experiments)
(Cheng Li and Wing Hung Wong) PNAS, 2001 (Image:Model-based analysis of oligonucleotide arrays)
(Cheng Li and Wing Hung Wong) Genome Biology, 2001 (Image:Model validation, design issues and standard error application)
Basic Research Applications of DChip
BioMicroCenter:“Stemness”: Transcriptional Pro.ling of Embryonic and Adult Stem Cells (Miguel Ramalho-Santos, Soonsang Yoon, Yumi Matsuzaki, Richard C. Mulligan, Douglas A. Melton) Science, 2002 (Image:Stemness)
(Rafael A. Irizarry, Bridget Hobbs, Francois Collin, Yasmin D. Beazer-Barclay, Kristen J. Antonellis, Uwe Scherf, Terence P. Speed) (Image:High Density Oligonucleotide Array Probe Level Data)
(Rafael A. Irizarry, Benjamin M. Bolstad, Francois Collin, Leslie M. Cope, Bridget Hobbs and Terence P. Speed) Nucleic Acids Research, 2003 (Image:Summaries of Affymetrix GeneChip probe level data)
(B. M. Bolstad, R. A. Irizarry, M. Astrand and T. P. Speed) Bioinformatics, 2003 (Image:Comparison of normalization methods)
(Beissbarth T, Speed TP) Bioinformatics, 2004 (Image:GOstat)