BME100 s2014:W Group1 L1

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Contents

OUR TEAM

Name: David Kish
Name: David Kish
Name: Khalid Al-Qahtani
Name: Khalid Al-Qahtani
Name: Danielle Eldred
Name: Danielle Eldred
Name: Maria Jose Quezada Valladares
Name: Maria Jose Quezada Valladares
Name: John Tobey
Name: John Tobey

LAB 1 WRITE-UP

Independent and Dependent Variables

Independent Variable: lipopolysaccharide dosage (mg) This variable is the one that is being modified throughout the experiment.

Dependent Variable: Inflammotin (units) Inflammotin in each patient will be the variable that varies according to the dosage implemented for their certain variable group.

Experimental Design

Groups
a. 22 Groups

b. 2 Control

   i) Each control group will be tested to see the natural measurements of Inflammotin.

c. Variable

  i) We will have twenty variable groups, one of each gender
  ii) each gender group will be subject to .5 mg doses
  iii) each gender group will be subject to 1 mg doses
  iv) each gender group will be subject to 1.5 mg doses
  v) each gender group will be subject to 2 mg doses
  vi) each gender group will be subject to 2.5 mg doses
  vii) each gender group will be subject to 3 mg doses
  viii) each gender group will be subject to 3.5 mg doses
  ix) each gender group will be subject to 4 mg doses
  x) each gender group will be subject to 4.5 mg doses
  xi) each gender group will be subject to 5 mg doses
  xii) each gender group will be subject to 5.5 mg doses
  xiii) each gender group will be subject to 6 mg doses
  xiv) each gender group will be subject to 6.5 mg doses
  xv) each gender group will be subject to 7 mg doses
  xvi) each gender group will be subject to 7.5 mg doses
  xvii) each gender group will be subject to 8 mg doses
  xviii) each gender group will be subject to 8.5 mg doses
  xix) each gender group will be subject to 9 mg doses
  xx) each gender group will be subject to 9.5 mg doses
  xxi) each gender group will be subject to  10mg doses

This was done to test half doses, three-quarter doses, and full doses to monitor efficiency to properly execute the experiment while also being fiscally responsible.

Age
a. 50+ We want a diverse age group to be tested therefore restrictions would inhibit our ability to get a proper measurement.


Number of subjects per group
a.10 people per group





Subject Selection

The criterion regarding the selection of test subjects are as follows.

  a)No test subject will be below the age of fifty.
  b)There will be two distinct groups of test subjects that are segregated by gender.

Based on the stated criterion a random selection will be implemented to avoid bias from swaying the integrity of the experiment. Control will be established after the subjects are selected by deciding which people are placed at which dosage.




Sources of Error and Bias

1)Age. We chose a broad age group that also had a broad exclusion. All those under the age of fifty are not being tested therefor we do not know efficiency in that age group, while having a broad range above fifty means that distinct effects within certain sections of our test subject will be neglected.

2)Ethnicity. Genetics play a primary role in how our body reacts therefor differing ethnicity may have different reactions. Without ensuring ethnic diversity we may neglect a certain culture within the experiment.

3)Life style. Certain people may exercise more or have a better diet meaning their body may react differently than someone who refuses to exercise and has a poor diet.

Control

 1) Age. We could create more specific groupings based on age to ensure we know the effects and efficiency of lipopolysaccharide within each specific age group.
 2)Ethnicity. With the randomization we could create sub classifications within the observed data to give proper attention to ethnic differences.
 3) Life style cannot be controlled. Instead we will simply factor it in as a variable that will change how the drug works within our uncontrolled society.







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