BME100 f2016:Group3 W8AM L3

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Contents

OUR TEAM

Name: Maddie Kleszcz
Name: Maddie Kleszcz
Name: Alexandria Castillo
Name: Alexandria Castillo
Name: Your name
Name: Your name
Name: Your name
Name: Your name
Name: Your name
Name: Your name
Name: Your name
Name: Your name

LAB 3 WRITE-UP

Descriptive Stats and Graph

1) Oral Thermometer

Gold Standard Measurements for Temperature:
Mean: 96.637709
Standard Deviation: 1.920911

Spree Measurements for Temperature:
Mean: 95.54489
Standard Deviation: 0.877778

Image:Average Temperature Chart.png


2) Pulse Ox

Gold Standard Measurements for Heart Rate:
Mean: 98.08977
Standard Deviation: 23.03054

Spree Measurements for Heart Rate
Mean: 98.9538
Standard Deviation:24.87754

Image:Average Heart Rate Chart.png



Inferential Stats

1) Oral Thermometer and Spree Band

Pearsons-R: 0.1509

Paired T-Test: 2.791*10^-20

Image:Average Temperature Paired T Test.png


2) Pulse Ox and Spree Band

Pearsons-R: 0.690806

T-Test: 0.427116

Image:Average Heart Rate Paired T Test1.png



Design Flaws and Recommendations

Based on the statistical evidence on temperature of the gold standard in comparison to the spree, the paired t-test concludes that the p-value of the experiment for temperature is about zero. Thus, this is less than alpha at 0.05 so we reject the null hypothesis that there is a relationship or equivalence between the data for temperatures for the spree and the Gold Standard. In addition, our correlation coefficient of 0.151 indicates that there is a weak, positive correlation between the temperatures recorded for the spree and the temperatures recorded for the Gold Standard. In conclusion, we can infer that overall the spree does not efficiently provide equivalent measurements of temperature to the Gold Standard.

Based on the statistical evidence on heart rate of the gold standard in comparison to the spree, the paired t-test concludes that the p-value of the experiment for heart rate is about 0.427. Since the p-value is greater than alpha at 0.05, we fail to reject the null hypothesis and cannot conclude that there is not a relationship or equivalence between the spree and the Gold Standard in heart rate. In addition, the



Experimental Design of Own Device

Our group's scientific question is “Does the method in which galantamine is inserted into the body affect how much of the actual drug goes into the bloodstream?” In order to test if our device is valid and safe, our team has decided to put our device through clinical trials. In our experiment, we will have the sample size of 120 patients with Alzheimer's disease. The reason for why we chose 120 patients is because this is our first clinical trial and our team wants to see if it works on a smaller scale, compared to a much bigger one. In our experiment, our independent variable is the form in which the patients receive galantamine, a drug for those suffering from dementia. This drug was created to improve memory, awareness, and the ability to perform daily functions. In this experiment, we will divide the group of 120 people into two groups. Thus, each group will have 60 people. In one group the patients will receive the pill version of galantamine. In the second group, they will have our device implanted in their mouths. Our dependent variable is how much of galantamine goes into the patient's blood system. The control in this experiment is the type of drug used. The suggested amount of galantamine a person uses in the form of a capsule is 16 milligrams. In the device there will be 250 micro-liters of the liquid form of galanatamine in the reservoir.


The way this experiment will work is that both the group one and two will take the drug at the same time and a blood test will be given an hour later. The caregiver will make sure that their patient receives their capsule at 8 in the morning and again at 4 PM. On the other hand, the implants will be set off to release the drug directly into the bloodstream at those exact times also. Then, an hour later after the drug was consumed, our group will go around taking blood samples of each patient while recording the data. They will measure the drug levels per volume blood. This experiment will be a week long. Our hypothesis is “if patients use our product than, more galantamine will be inserted into the bloodstream because our product injects the drug directly into a vein located under the tooth”. After conducting this experiment we will review our results and see if our hypothesis is correct. We will be using the unpaired version of the t-Test due to the fact that we are comparing the results of two different groups.


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