BME100 f2014:Group14 L3

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Contents

OUR TEAM

Name: Fatima Sanchez Garcia
Name: Fatima Sanchez Garcia
Name: Brianna Steele
Name: Brianna Steele
Name: Lemlem Brook
Name: Lemlem Brook
Name: Claudia Czekaj
Name: Claudia Czekaj
Name: Taylor Brown
Name: Taylor Brown
Name: Ciaran McGirr
Name: Ciaran McGirr

LAB 3A WRITE-UP

Descriptive Statistics

The means of the temperatures from the gold standards and the Spree are essential in understand if the Spree device is effective or not. The mean of the temperature using the Spree (variable 1) was 103.6 degree fahrenheit and the mean using gold standards (variable 2) is 97.52 degree fahrenheit. The mean of the heart rates using the Spree was 92.57 beats per minute and the gold standards was 91.53 beats per minute.

The standard deviation and the standard error are two important components of the statistics that will help enable users to understand the Spree.




Graphing

Image:Lab_4_BME_Temperature_graph_1.png


Image:Lab4BMEtemperatureGraph2.png

Image:lab4graph2.png


Image:lab4graph1.png
For both of the graphs with numbered intervals on the x-axis, the numbers correspond to the measurement intervals accordingly:
1=Pre-Walk/Indoor-1
2=Pre-Walk/Indoor-2
3=Pre-Walk/Indoor-3
4=Pre-Walk/Indoor-4
5=Pre-Walk/Indoor-5
6=Walk 1
7=Walk 2
8=Walk 3
9=Walk 4
10=Walk 5
11=Walk 6
12=Walk 7
13=Walk 8
14=Walk 9
15=Walk 10
16=Walk 11
17=Walk 12
18=Cool Down/Indoor-1
19=Cool Down/Indoor-2
20=Cool Down/Indoor-3
21=Cool Down/Indoor-4
22=Cool Down/Indoor-5

Inferential Statistics

Image:Heart1-lab3.PNG


Image:Temp1-lab3.PNG



Comparing the data tables and charts of the accuracy of the Spree Band to the pulse ox and oral thermometer, all of the data points led to the conclusion that the correlation between the Spree Band and the thermometer when testing for temperature were not closely related, as the p-value was -0.0064. For the blood pressure, the Spree Band and pulse ox both came to a very close result, allowing the team to understand the Spree Band is a good replacement for the pulse ox, but not for the temperature due to the large difference in results of 6.08 degrees.

Summary/Discussion

In order to determine if the Spree is indeed an accurate replacement for traditional temperature and blood pressure measuring systems, we had to test and compare the product to a usual thermometer and pulse ox. When the two measurements are compared it can be concluded that the Spree provides an accurate reading of blood pressure but not temperature.

Looking at the descriptive data for temperature, we can see that the average temperature for the Spree (103.6 degrees Fahrenheit) and thermometer (97.52 degrees Fahrenheit) vary by 6.08 degrees and show -0.00664, or no correlation. This information is further validated by the inferential data. The large difference between the critical t values and those found, show a significant amount of difference between the two devices. In regards to temperature, the Spree is not an appropriate substitute.

The blood pressure reading between the Spree and pulse ox were very similar. The two means were 92.57 bpm (Spree) and 91.53 bpm (pulse ox), a difference of only 1.04. The Pearson's r value for this test was .98, an ideal positive correlation meaning the data was almost identical. According to the inferential statistics, the critical t value and the calculated t value very slightly, indicating that there is not a significant difference between the results of the two devices. The Spree provides a generally accurate reading for blood pressure.

There was quite a bit of potential for error within this test. When taking averages, we did not take into account that the time intervals for the measurements differed; measurements were taken every two minutes during the two resting periods as opposed to every five minutes during activity. Moreover, not all the data readings were recorded for each group due to technical issues with the product. Another technical defect that may have caused error, is the placement of the Spree. Sweat from the forehead, or its constant contact with the sun could have skewed the readings. The timing for the temperature and blood pressure readings were off at times, with our group recording data a little earlier or later than the time specified.

To improve the overall function of the Spree, the company should use actual temperature readings instead of giving a scaled 1-4 value. The placement of the Spree is also another flaw. Placing it near the core or abdominal part of the body would provide better temperature readings and avoid influence from external factors such as sunlight. Technological changes need to be made to ensure better bluetooth connection, as well as making it available to a greater population, not just iPhone users.

LAB 3B WRITE-UP

Target Population and Need

Hormone Observation Patch Intermediary and Interface, or HOPII, targets women ages 13-65 who are having key hormone imbalances. Specifically women dealing with general hormone issues, who are pregnant, on birth control, going through menopause, puberty, thyroid problems or acne. The device will measure estrogen, progesterone, testosterone and follicle stimulating hormones. This monitoring device will be placed on the outer side of the upper arm and HOPII will measure the hormone levels every hour and record it for easy access by a doctor later. This monitoring device can be utilized for temporary or long term use, depending on the situation of the patient.

Device Design

This device contains a removable chip and replaceable patch that will be needed to be changed out everyday. Since blood testing is most accurate, there will be painless micro-needles underneath the patch that will go directly into the bloodstream of the patient. HOPII will also come with a phone application. With the Bluetooth feature enabled in the device, a patient will be able to see charts of normal hormone levels and compare to themselves any time of the day. In addition, if hormone levels are dangerously imbalanced, the application will alert the patient to make an appointment with their doctor as quickly as possible.

The link to view the device in Tinkercad:
https://tinkercad.com/things/4kfmPFFWZ8Ag-hopii-bme-100-lab-device


Dataset and Statistics

Dataset

To test the HOPii, we compared it to the results of a blood test. We used 60 test subjects: 20 women who have started their menstrual cycles, 20 pregnant women, and 20 post-menopausal women. The same 60 women were used to test the measurements of the hormones progesterone, estradiol, follicle-stimulating, and testosterone. We compared the results from blood tests to the average hormone reading given by the HOPii. We did this because the HOPii takes hourly readings while a blood test can only be administered, at most, once a day.

Image:Progesterone_Dataset.PNG Image:Estradiol_Dataset.PNG Image:FSH_Dataset.PNG Image:Testosterone_Dataset.PNG


Descriptive Statistics

Progesterone:

HOPii Average: 32.49933

Gold Standard Average: 31.99617

HOPii Standard Dev.: 60.49073

Gold Standard Stan. Dev.:58.69807

HOPii Stan. Error: 7.80932

Gold Standard Stan. Error: 7.577889

Testosterone:

HOPii Average: 38.51667

Gold Standard Average: 38.21667

HOPii Standard Dev.: 17.3161

Gold Standard Standard Dev.: 17.34075

HOPii Stan. Error: 2.235498

Gold Standard Stan. Error: 2.238682

Estradiol:

HOPii Average: 596.35

Gold Standard Average: 596.26

HOPii Standard Dev.: 938.0611

Gold Standard Standard Dev.: 938.0362

HOPii Stan. Error: 121.1032

Gold Standard Stan. Error: 121.1

Follicle-Stimulating Hormone

HOPii Average: 30.905

Gold Standard Average: 30.8285

HOPii Standard Dev.: 39.48229

Gold Standard Standard Dev.: 39.4443

HOPii Stan. Error: 5.097142

Gold Standard Stan. Error: 5.092237

Inferential Statistics

T-test for Testosterone


T-test for Progesterone


T-test for Follicle Stimulating Hormone


T-test for Estradiol


Graph

Image:BME_Device_Progesterone_Avg.PNG


Image:BME_Device_Estradiol_Avg.PNG


Image:BME_Device_FSH_Avg.PNG


Image:BME_Device_Testosterone_Avg.PNG




References

"Follicle-stimulating Hormone (FSH) Blood Test: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, 30 Sept. 2013. Web. 14 Oct. 2014.

"Serum Estradiol Measurement." Lab Tests & Results. Medical University of South Carolina, 2014. Web. 15 Oct. 2014.

"Serum Progesterone: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, 25 Apr. 2013. Web. 15 Oct. 2014.

"Testosterone: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, 20 Feb. 2014. Web. 15 Oct. 2014.



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