BIOL368/F14:Class Journal Week 7

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Chloe Jones

  1. What was the easiest aspect of reading/understanding the your journal club article?
    • I don’t think I can point to an easy aspect when reading the article because the article was pretty difficult for me to read. What did help with my understanding of the overall article was Figure.1. Once I understood the structure of the protein and how it was positioned I was able to get a better understanding of the article and see how the different regions played a part in the attachment of the membrane. I also think it really helped there were introductions on some of the pictures and the fact that they were thoroughly explained. The color coding in the pictures also aided in my understanding of the overall HIV-1 gp120 envelope glycoprotein.
  2. What was the most difficult aspect of reading/understanding your journal club article?
    • What made the article difficult to read was the fact that it was a complex scientific concept so it took a longer time to understand. Although the article was fairly short everybody paragraph had to be examined in depth for me to get a clear understanding of what was going on and be able to reference it as I advanced in the article. The pictures at first were very intimidating, and the reading did not introduce all the pictures which made it hard to understand at times. Also, I felt as though you had to know the pictures in order to move on to the next picture set. Overall, the article was dense and just required a good portion of time to completely comprehend the purpose of the study.
  3. What new question do you have about HIV that you would like to answer?
    • I would like to compare 3 non progressors to 3 moderate progressors and see if the number at which they vary is enough to determine that there is a differentiation between the group . In figure 2A of the Markham et al. article which demonstrates the slope of diversity, there is an overlap between the non progressor group and moderate progressor group. I would be curious to see if the subjects within the groups took on a title that clearly differentiated them.

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Chloe Jones 03:46, 15 October 2014 (EDT)Chloe Jones

Isabel Gonzaga

  1. What was the easiest aspect of reading/understanding the your journal club article?
    • Currently, I am learning about protein structures and folding in my Biochemistry course. Because this material was fresh in my mind and I am familiar with some of the related terminology, I was able to better grasp some of the concepts presented by this article. Without this background information, I would have struggled greatly.
  2. What was the most difficult aspect of reading/understanding your journal club article?
    • The most difficult aspect of this article was how densely worded the passage was, and being unfamiliar with the terminology. Also, not having clear divisions differentiating the text between 'introduction' 'methods/results' and 'discussion' made it more challenging to follow than other articles I have read. The introduction was also much less detailed than the previous Markham et al. paper, and the footnote format to expand on background information from the cited literature was sometimes confusing. The combination of these factors really increased the difficulty in understanding this paper.
  3. What new question do you have about HIV that you would like to answer?
    • I am interested in continuing to compare Diagnosed, Progressing, and Non-trending groups in the development of AIDS. I would like to see how their protein structures change and develop over time, with respect to their individual groups

Isabel Gonzaga 00:36, 15 October 2014 (EDT)

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Nicole Anguiano

  1. What was the easiest aspect of reading/understanding the your journal club article?
    • There was very little that was easy to understand about this article. The figures made it slightly easier to understand, but ultimately the article was extremely complex.
  2. What was the most difficult aspect of reading/understanding your journal club article?
    • This article assumed that the reader knew a decent amount about the subject that it was referring to. The passage wasn't long, probably due to the absence of explanation. However, the article was extremely dense and packed with terminology. The figures only did so much to explain what was being talked about in the article. The discussion was particularly difficult due to the expansion upon already difficult concepts. Also, the inclusion of methods and discussion in the references made following the paper more challenging than if the material had been included throughout the work.
  3. What new question do you have about HIV that you would like to answer?
    • I want to compare the clones of subjects 14 and 15 and see how they are similar and different based on their protein structures. I want to see if any similarity remains between them throughout the various visits.


Nicole Anguiano 02:59, 15 October 2014 (EDT)
Nicole Anguiano
BIOL 368, Fall 2014

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