Arlot:Legoffx
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- LE GOFF Xavier, PhD, Research Associate- CNRS
- UMR6290-CNRS. Institute of Genetics and Development of Rennes
- University of Rennes1
- 2 avenue du Professeur Léon Bernard
- 35043 RENNES Cedex
- phone : 33 (0)223 234 527
- Fax:33(0) 223 234 478.
- email : xavier.le-goff@univ-rennes1.fr
Education
- 1996 Doctor in Biological Sciences with Honours, University of Rennes 1
- 2006 Diploma HDR- University of Rennes 1
Position
- CNRS Research Associate - UMR6290-CNRS -IGDR
- Team: “Kidney cancer: Molecular Basis of Tumorigenesis”
Distinction
- -Prix Bretagne Jeune Chercheur, 2001 “Sciences Biologiques et Médicales”
- -Médaille de la Ville de Rennes, 2003
Research Interest
- Cell cycle
- Cell polarity and cytoskeleton
- Cellular fate and dynamic distribution of proteins
- Yeast genetics
- Cell signalling
- Cancer
- I am currently investigating the cellular fate of heterologous proteins expressed in the fission yeast Schizosaccharomyces pombe. I am particularly interested to understand the cellular and molecular mechanisms regulating their dynamic distribution within cells and their partition at time of cell division. I am studying protein-protein interactions and post-translational modifications regulating protein degradation. I am focusing on how protein expression would modify morphogenesis and cell viability (proteotoxicity) in fission yeast. For that purpose, I use and develop genetic tools (conditional mutants, genetically modified yeast strains expressing tagged protein) and cell biology methods (fluorescence live cell imaging, FRAP).
