20.109(F08):Anna YingFei Module3

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Anna's and YingFei's Research Proposal

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Using Cysteine-Knot Proteins to Engineer Drugs for Cancer Treatment

Papers we are using as resources:

[1]

[2]

[3]

[4]

Key role of glutamic acid for the cytotoxic activity of the cyclotide cycloviolacin O2 [5]

Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists [6]

A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability [7]

Cyclotides: A Novel Type of Cytotoxic Agents [8]

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