X:Research: Difference between revisions

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[http://openwetware.org/wiki/X-Lab X-Laboratory]
[http://openwetware.org/wiki/X-Lab return to X-Laboratory]
 
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'''X-Laboratory'''  </font> <br>
(Under Development) <br>
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.med.tsinghua.edu.cn School of Medicine], [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
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Research Projects
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Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
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One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as biomolecular sensors and actuators. [http://openwetware.org/wiki/User:Xiaodong_Liu#Publications relevant publications]
1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels


a. Excitation-transcription coupling by Ca<sub>V</sub>1 signaling in neurons


b. Design of specific modulators of Ca<sub>V</sub>1 subtypes


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2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging


a. Design and characterizations of genetically-encoded probes/sensors for key biological signals


b. Innovative platform of probe/imaging system/algorithm to expand 3<sup>3</sup>-FRET to microscopic and macroscopic imaging


 
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'''''re-constitution''''' of ion channels’ functions & pathophysiology.
 
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Revision as of 09:19, 26 July 2014

return to X-Laboratory


1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels

a. Excitation-transcription coupling by CaV1 signaling in neurons

b. Design of specific modulators of CaV1 subtypes

2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging

a. Design and characterizations of genetically-encoded probes/sensors for key biological signals

b. Innovative platform of probe/imaging system/algorithm to expand 33-FRET to microscopic and macroscopic imaging


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