X:Research: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
No edit summary
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
<br>
<br>
<center>
<center>
<font face="Helvetica" size=6 color=#339900>
<font face="Helvetica" size=6 color=#339900>
'''X-Laboratory'''  </font> <br>  
'''Synthetic Electrophysiology of Ion Channels'''  </font> <br>  
(Under Development) <br>
 
 
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
<br>
<br>
Line 36: Line 36:
|width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"|
|width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"|
<font face="Helvetica" size=4>
<font face="Helvetica" size=4>
Research Projects
 
To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the
'''''re-constitution''''' of ion channels’ functions & pathophysiology.
</font><br>
</font><br>


<font face="Helvetica" size=3>
<font face="Helvetica" size=3>


Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as biomolecular sensors and actuators. [http://openwetware.org/wiki/User:Xiaodong_Liu#Publications relevant publications]




Revision as of 20:14, 22 October 2013


Synthetic Electrophysiology of Ion Channels


Principle Investigator: Xiaodong Liu, Ph.D.

Department of Biomedical Engineering at School of Medicine, Tsinghua University

To apply engineering principles onto both biological entities (synthetic ion channels & modulators etc.) and physical components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the re-constitution of ion channels’ functions & pathophysiology.









Retrieved from "https://openwetware.org/mediawiki/index.php?title=X:Research&oldid=742210"