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'''X-Laboratory'''  </font> <br>  
'''Synthetic Electrophysiology of Ion Channels'''  </font> <br>  
(Under Development) <br>
 
 
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
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Research Projects
 
To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the
'''''re-constitution''''' of ion channels’ functions & pathophysiology.
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1. Sensory signaling via channel complex (''e.g.'', TRP/GPCR or Ca<SUB>V</SUB>/CaM).
2. Novel modulators of Ca<SUP>2+</SUP> channels as tools to pursue molecular physiology.


3. Design and application of genetically encoded (optical) sensors.
4. Mechanisms and engineering of membrane nanoporation.<br>




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Journal Club
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2010
ZHANG Yue 8/12 FRET-based FMT
XU Yanyan 9/10 GPCR/Sensory Neuron
ZHAO Shan (from Du Lab) 9/25 Remotely Triggerable Drug Delivery Systems


LIU Qing  10/15 reversible photoswitchable rsTagRFP for pcFRET


YU Tao (from Song Lab) 10/22 Tetracycline-regulatable factors with distinct dimerization
domains allow reversible growth inhibition by p16


XIE Xin  10/29





Revision as of 20:14, 22 October 2013


Synthetic Electrophysiology of Ion Channels


Principle Investigator: Xiaodong Liu, Ph.D.

Department of Biomedical Engineering at School of Medicine, Tsinghua University



To apply engineering principles onto both biological entities (synthetic ion channels & modulators etc.) and physical components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the re-constitution of ion channels’ functions & pathophysiology.