X-Lab

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[[X-Lab|Home]]|[[X-Lab|主页]]
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LAB DESCRIPTION
LAB DESCRIPTION
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Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
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The central focus of our lab is ion channels, the third largest superfamily of signaling proteins. We are particularly attracted by the amazing capabilities of ion channels in sensing exogenous stimuli of diverse modality, such as transmembrane potentials, ionic signals, mechanical forces and electromagnetic radiations. '''How exactly would ion channels sense, transduce and process the stimuli (i.e., energy and information) at submolecular, molecular and cellular levels?''' Based on these core biophysics, we pursue mechanistic understanding, pathophysiological ramifications and bioengineering innovations, of transmembrane signaling via ion channels, especially those related to sensory functions, including vision, taste, hearing and other less-studied modalities.
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One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as sonoporation, channel modulators, biomolecular sensors etc. [http://openwetware.org/wiki/User:Xiaodong_Liu#Publications relevant publications]
 
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[[X:BS20013|Attention: 刘晓冬研究组(X-LAB)本科生研究课题]]
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== Lab News ==
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'''JIANG Peng from X-Lab presented research at Tsinghua BoShiShen Symposium of Life and Biomedical Sciences, Oct 15-16, 2011, Beijing
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[[Image:JIANGPeng2011.jpg|thumb|left|100x100px]]
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'''X-Lab presented research at CaBP17, July 17-20, 2011, Beijing
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LIU Nan ''et al.''(poster)
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XU Yanyan ''et al.'' (poster)
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LIU Xiaodong (invited talk)
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'''The X-lab is starting to accept PTN students for research rotations!'''
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http://life.tsinghua.edu.cn/home/announce/1613.html
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http://www.nibs.ac.cn/?act=view&id=2741
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'''Postdoctoral Position Openings'''
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http://www.nature.com/naturejobs/science/jobs/191089-Postdoctoral-Fellow-Tsinghua-University
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'''X-Lab (LIU Qing, XIE Xin and LIU Xiaodong) presented the poster:
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CHARACTERIZATION OF QUANTITATIVE FRET SENSORS FOR FLUORESCENCE MOLECULAR TOMOGRAPHY'''
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Author Block: Qing Liu, Xin Xie, Yi Zhang, Yanyan Xu, Yue Zhang, Xin Liu, Jing Bai, Xiaodong Liu.
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Tsinghua University, Beijing, China.
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during Biophysics Society Annual Meeting, March 2011 at Baltimore, MD, USA
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== Updates ==
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'''Individual Meetings (Starting from 2011/10)
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17th “International Biophysics Congress” (IAPUB)  Oct 30-Nov 3 Beijing, China
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http://www.17ibc.org/
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55th Annual Meeting of Biophysical Society March 5 - 9, 2011
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http://www.biophysics.org/2012meeting
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Journal Club (Jointed with DU Lab and SONG Lab)
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== 2010 ==
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ZHANG Yue 8/12 FRET-based FMT
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XU Yanyan 9/10 GPCR/Sensory Neuron
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ZHAO Shan (from Du Lab) 9/25 Remotely Triggerable Drug Delivery Systems
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LIU Qing  10/15 reversible photoswitchable rsTagRFP for pcFRET
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YU Tao (from Song Lab) 10/22 Tetracycline-regulatable factors with distinct dimerization
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domains allow reversible growth inhibition by p16
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TSE Yan Franco (XIE Xin)  10/29 Calcium Channels
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NIU Pengxia (from DU Lab) 11/5 fuorescent structural DNA nanoballs functionalized with phsphate-linked nuceotide triphosphates
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LI Xuesong (from SONG Lab) 11/19 global and local fmri signals driven by neurons defined optogenetically by type and writing
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Claudia Wittkowske (from DU Lab) 11/26 "Glioblastoma stem-like cells give rise to tumour endothelium"
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XUE Wenwen 12/10 bacteria magnetosome
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YU Tao (from SONG Lab) 12/17 optical dimerization
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XU Yanyan 12/24 Functional connectivity in the retina at the resolution of photoreceptors
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== 2011 ==
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ZHAO Shan (from Du Lab) 1/7 Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones
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LI Xuesong (from SONG Lab) 2/25 "Genetic dissection of an amygdala microcircuit that gates conditioned fear" and  "Encoding of conditioned fear in central amygdala inhibitory circuits"
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LIU Nan 3/28 Salty Taste
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[[Image:X.png|thumb|left|400x400px|X-LAB. ]]
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<br>The following positions are currently available:
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'''Postdoctoral Fellows'''
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'''Ph.D. Students'''
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'''Masters' Students'''
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Please send email to [mailto:liuX.tsinghua@gmail.com Dr. Liu] if you are interested. Include your CV and a brief description of your career goals.
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We also welcome '''undergraduate students''' (especially from major research universities in Beijing) to conduct research in our lab on thesis projects.
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All above positions can start immediately.
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Revision as of 13:05, 4 November 2012


X-Laboratory

(跨膜与感觉信号转导研究组)

Principle Investigator: Xiaodong LIU, Ph.D. (刘晓冬)

Department of Biomedical Engineering, School of Medicine
School of Life Sciences
at Tsinghua University




Welcome to the X-Lab!


LAB DESCRIPTION

The central focus of our lab is ion channels, the third largest superfamily of signaling proteins. We are particularly attracted by the amazing capabilities of ion channels in sensing exogenous stimuli of diverse modality, such as transmembrane potentials, ionic signals, mechanical forces and electromagnetic radiations. How exactly would ion channels sense, transduce and process the stimuli (i.e., energy and information) at submolecular, molecular and cellular levels? Based on these core biophysics, we pursue mechanistic understanding, pathophysiological ramifications and bioengineering innovations, of transmembrane signaling via ion channels, especially those related to sensory functions, including vision, taste, hearing and other less-studied modalities.





Attention: 刘晓冬研究组(X-LAB)本科生研究课题

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