X-Lab

X-Laboratory

(跨膜与感觉信号转导研究组)

Principle Investigator: Xiaodong LIU, Ph.D. (刘晓冬)

Department of Biomedical Engineering, School of Medicine
School of Life Sciences
at Tsinghua University

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Welcome to the X-Lab! LAB DESCRIPTION Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations. One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca2+ or K+) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to Liu X. et. al. Nature. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as sonoporation, channel modulators, biomolecular sensors etc. relevant publications Lab News Ion Channels Lectures Offered 2012 Spring through PTN Course 清华进展和讨论生物学专题讨论之“细胞膜离子通道基础”专题模块 Two New Grants Awarded to X-Lab "基于钙通道信号通路及microRNA逻辑电路选择性识别并修复神经退行性病变" 清华信息科学与技术国家实验室（筹）学科交叉基金，项目经费为15万，执行时间为2012年1月-2013年12月. "重要跨膜信号的光监控“ 国家自然科学基金面上项目，项目经费为60万，执行时间为2012年1月-2015年12月. Opening Positions of X-Lab: starting to accept applications from Nov. 2011 until filled http://talent.sciencenet.cn/info.aspx?id=11325 X-Lab Students attended Tsinghua BoShiSheng Symposium of Medical School, Nov 19, 2011, Beijing JIANG Peng (Prize for Excellent Oral Talks) LIU Nan, et al. (Poster) TANG Ji, et al. (Poster) JIANG Peng from X-Lab received "Best Poster Award" at 17th “International Biophysics Congress” (IAPUB) Oct 30-Nov 3 Beijing, China See also, BME Departmental News Congratulations, Peng! LIU Xiaodong presented X-Lab research as an invited talk at Asia Communications and Photonics Conference (ACP2011), Nov. 13-16, 2011, Shanghai JIANG Peng from X-Lab presented research at Tsinghua BoShiShen Symposium of Life and Biomedical Sciences, Oct 15-16, 2011, Beijing X-Lab presented research at CaBP17, July 17-20, 2011, Beijing LIU Nan et al.(poster) XU Yanyan et al. (poster) LIU Xiaodong （invited talk) The X-lab is starting to accept PTN students for research rotations! http://life.tsinghua.edu.cn/home/announce/1613.html http://www.nibs.ac.cn/?act=view&id=2741 Postdoctoral Position Openings http://www.nature.com/naturejobs/science/jobs/191089-Postdoctoral-Fellow-Tsinghua-University X-Lab (LIU Qing, XIE Xin and LIU Xiaodong) presented the poster: CHARACTERIZATION OF QUANTITATIVE FRET SENSORS FOR FLUORESCENCE MOLECULAR TOMOGRAPHY Author Block: Qing Liu, Xin Xie, Yi Zhang, Yanyan Xu, Yue Zhang, Xin Liu, Jing Bai, Xiaodong Liu. Tsinghua University, Beijing, China. during Biophysics Society Annual Meeting, March 2011 at Baltimore, MD, USA Updates Individual Meetings (Starting from 2011/10) 17th “International Biophysics Congress” (IAPUB) Oct 30-Nov 3 Beijing, China http://www.17ibc.org/ 55th Annual Meeting of Biophysical Society March 5 - 9, 2011 http://www.biophysics.org/2012meeting