Veit-Simon Eckle

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(Research Interests:)
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(Lebenslauf)
 
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D-72072&nbsp;Tübingen<br>
D-72072&nbsp;Tübingen<br>
Tel.&nbsp;++49-7071/29&nbsp;8&nbsp;11&nbsp;59<br>
Tel.&nbsp;++49-7071/29&nbsp;8&nbsp;11&nbsp;59<br>
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Fax&nbsp;++49-7071/29&nbsp;2&nbsp;50&nbsp;73<br>
 
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==== Research Interests:====
 
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My research focuses on the effects of volatile and intravenous anesthetics on GABA(A) and glycine receptor-mediated neurotransmission in the spinal ventral horn. This specific area of the spinal cord seems to play a key role in providing anesthetic-induced immobility. Organotypic slice cultures are well established in our lab and serve as a model for pharmacologic studies in intact neuronal networks.
 
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:SpinalCord |Spinale Mechanismen der Anästhesie]]
 
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:Alternativ |Alternative Wirksamkeits-Testung von Botulinum Toxin B an Nerven-Muskel-Zellkulturen in vitro]]
 
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:Ballon |Intrajugulärer Ballon-Katheter zur Prävention von Luftembolie]]
 
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| valign="top" |'''Residency:'''
 
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|valign="top" | [http://www.medizin.uni-tuebingen.de/Patienten/Kliniken/Anaesthesiologie+und+Intensivmedizin.html Department of Anesthesiology], [http://www.uni-tuebingen.de University of Tübingen]<br>
 
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[http://www.mri.tum.de/anaesthesie Department of Anesthesiology], [http://www.med.tum.de/ Klinikum rechts der Isar], Munich<br>
 
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[http://www.bk-trier.de/bk_trier/Medizin-Pflege/fachabteilungen/anaesthesie/index.php Department of Anesthesiology], [http://www.bk-trier.de/bk_trier/index.php Brüderkrankenhaus Trier]<br>
 
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| valign="top" | '''Fellowship:'''
 
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|valign="top" | Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, [http://www.medicine.virginia.edu/clinical/departments/anesthesiology/research/slobodan-todorovic.html Todorovic Lab]) and Pharmacology (Prof. E. Perez Reyes [http://people.virginia.edu/~ebp8n/ Perez-Reyes Lab]), University of Virginia, Charlottesville, Virginia, USA<br> 
 
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| valign="top" | '''Awards: '''
 
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| valign="top" |3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the [http://www.dgai.de/ DGAI], Congress of Anesthesiology and Intensive Care Medicine, September 2012<br>
 
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[http://www.wakwin.de/tiki-index.php WAKWIN] Mentee, [http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care], 2010<br>
 
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Resident Travel Award, [http://www.snacc.org/ SNACC] Meeting, Orlando 2008
 
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| valign="top" | '''Patent: '''
 
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| valign="top" | [http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013004739&recNum=273&docAn=EP2012063023&queryString=%28IC/a61m%29%20&maxRec=34094 link] Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
 
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| valign="top" | '''Memberships: '''
 
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| valign="top" |[http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care]<br>[http://www.euroanaesthesia.org/ European Society of Anaesthesiology]<br> Associate Faculty Member of the [http://f1000.com/ Faculty of 1000 Medicine]
 
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==== Selected Publications: ====
 
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* Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E. Mechanisms by which a CACNA1H mutation found in epilepsy patients increase seizure susceptibility. J Physiol. 2013 Nov 25. [http://www.ncbi.nlm.nih.gov/pubmed/24277868 PubMed]
 
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* Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013 Dec 2. [http://www.ncbi.nlm.nih.gov/pubmed/24299204 PubMed]
 
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* Eckle VS, Antkowiak B. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. Neuroscience. 2013 Dec 3;253:165-71. [http://www.ncbi.nlm.nih.gov/pubmed/23994185 PubMed]
 
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* Eckle VS, Hauser S, Drexler B, Antkowiak B, Grasshoff C. Opposing actions of sevoflurane on GABAergic and glycinergic synaptic inhibition in the spinal ventral horn. PLoS One. 2013;8(4):e60286. [http://www.ncbi.nlm.nih.gov/pubmed/23565218 PubMed]
 
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* Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 [http://www.ncbi.nlm.nih.gov/pubmed/22491022 PubMed]
 
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* Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. [http://www.ncbi.nlm.nih.gov/pubmed/22134411 PubMed]
 
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* Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. [http://www.ncbi.nlm.nih.gov/pubmed/21821734 PubMed]
 
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* Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. [http://www.ncbi.nlm.nih.gov/pubmed/20363234 PubMed]
 
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* Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. [http://www.ncbi.nlm.nih.gov/pubmed/19760252 PubMed]
 
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* Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. [http://www.ncbi.nlm.nih.gov/pubmed/19034096 PubMed]
 
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* Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. [http://www.ncbi.nlm.nih.gov/pubmed/14713542 PubMed]
 

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Dr. Veit-Simon Eckle

Waldhörnlestr. 22
D-72072 Tübingen
Tel. ++49-7071/29 8 11 59

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