User talk:Jeremy S. Myers

Hello, Jeremy S. Myers! This is a welcome message from OpenWetWare. By the way, we've announced you on the home page! You can leave messages to any OWW member by editing their User_talk pages like this one. And don't forget to personalize your User Page so that we can get to know you better! We've included some tips below to get you started.

Basic Wiki Instructions

• Don't be afraid to edit! As with all pages on the wiki, all versions are saved so its easy to undo. If you have any questions feel free to email admin at openwetware dot org.

1. Start off by clicking the 'edit' button to the right of this section, or at the top of the page.
2. Now you should see the text of this section as text within an editor box. There are several buttons in the editor box, but don't worry about those for now. Just type something in the box, scroll down to the bottom, and hit the 'Preview' button.
3. You should see the web-page and text box views, but now with your edits! Don't forget to save your changes by clicking 'Save Page'!
4. Editing pages is as easy as that. There are of course many ways to format your text. The easiest way to learn is to find an OWW page with the formatting you like, click on the edit button again, and see for yourself how it was created in the text box. Here's an extensive list of formating examples. Or look at this OpenWetWare introductory tutorial.
5. When you are done, remove these instructions by clicking the edit button for this section again, erase everything you see in the text box and click 'Save Page'. (And remember you can always retrieve these by clicking on the 'history' tab at the top of this page.)

Note that these instructions apply to any page on OWW. Feel free to contribute to OWW by editing pages to add content, update them, or even correct mistakes. OWW relies on an active community to manage our growing resource of open access information, and we need your help!

Personal/Lab Info

Targeted Proteomics: Fundamental Approach for Targeted Therapy

The human proteome is the protein complement of human genome, the primary functional components of a cell, and key to understanding human disease.

Proteomics is the analysis of proteins that make-up the proteome and employs various advanced biotechnologies to understand the dynamic regulation of the proteome.

Mass spectrometry-based analysis is the prevailing tool for proteomics and has the potential to identify indicators of disease, identify targets for treatment, and monitor treatment response. Many different mass spectrometry proteomics platforms exist. Global proteomic analyses are the prominent platforms applied in cancer proteomics, because they attempts to provide rapid identification and quantitation of all proteins in the proteome. However, these platforms face a number of challenges:

1. Proteome variation is common resulting from genetic differences between individuals and genetic differences within in each of the 100 trillion cells in a human body which mutate at an estimated 10,000 mutations in each cell per day.

2. Global protein identification is dependent on the relative abundance of proteins in the proteome. Many regulatory changes in the proteome that define cell activity are relatively low abundant protein modifications.

Therefore, proteomic variation contributing to disease and useful in improving therapy is not easily identified.

Targeted proteomics combines genetics, molecular biology, mass spectrometry-based proteomics, and bioinformatics and addresses these challenges by targeting the fraction of the proteome most relevant to disease.

Leveraging diverse research experience and advanced mass spectrometry-based proteomics, we are providing new insight to human disease and helping to develop and improve chemotherapeutics tailored for specific cancer types.