User:Xi Chen: Difference between revisions
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[[User:Xi_Chen:SynBioLib|Synthetic Biology Library]] | [[User:Xi_Chen:SynBioLib|Synthetic Biology Library]] | ||
===Personal life=== | ===Personal life=== | ||
[http://dl.dropbox.com/u/11482398/Ruoyu/%28GIF-3%29%20Bad-Guy-Is-You.gif Ruoyu Pic 1 (1 month, "Bad guy is you!")] | *[http://dl.dropbox.com/u/11482398/Ruoyu/%28GIF-3%29%20Bad-Guy-Is-You.gif Ruoyu Pic 1 (1 month, "Bad guy is you!")] | ||
[http://dl.dropbox.com/u/11482398/Ruoyu/%28GIF-4%29%20Sway-with-me.gif Ruoyu Pic 2 (1 month, "Sway with me!")] | *[http://dl.dropbox.com/u/11482398/Ruoyu/%28GIF-4%29%20Sway-with-me.gif Ruoyu Pic 2 (1 month, "Sway with me!")] | ||
*[http://dl.dropbox.com/u/11482398/Ruoyu/%28GIF-2%29%202012-03-17%20Rianne_with_toy.gif Ruoyu Pic 3 (1 month, Ruoyu with toy] |
Revision as of 09:56, 29 March 2012
Xi Chen
I am currently a post-doc fellow in the lab of Andrew D. Ellington in the University of Texas at Austin. I am also a visiting fellow of the Yin Lab in Wyss Institute of Harvard University.
Research
The first 3 years of my graduate study were spent primarily on engineering ribozyme-based RNA regulators in mammalian cells. Although I have created a few unpublished RNA regulators that work minimally (by my standard), I mainly focused on the development of a method to directly select physiologically active ribozymes in mammalian cells, and a kinetic model to analyze and direct such selections. I then extended this kinetic model to analyze and predict the performance of ribozyme- and deoxyribozyme-based sensors in vitro and in vivo.
Since late 2008, I became interested in enzyme-free DNA circuits initially developed by the Winfree Lab and the Pierce Lab in Caltech. I have started designing and executing similar circuits for the purpose of biosensing, pattern formation, and chemical synthesis.
After graduation, I stayed in the Ellington Lab to keep working on DNA circuits.
Selected Publications
(Note: * denotes corresponding author or co-corresponding author)
- Chen X*. (in press) Expanding the Rule Set of DNA Circuitry with Associative Toehold Activation. J. Am. Chem. Soc. doi:10.1021/ja206690a
- Li B, Ellington AD, Chen X*. (2011) Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods. Nucleic Acids Res. doi: 10.1093/nar/gkr504
- Eckhoff G, Codrea V, Ellington AD, Chen X*. (2010) Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy-driven DNA amplifier. J. Syst. Chem. 1:13
- Chen X, Ellington AD. (2010) Shaping up nucleic acid computation (Review). Curr. Opin. Biotechnol. 21(4):392-400
- Chen X, Ellington AD. (2009) Design Principles for Ligand-Sensing, Conformation-Switching Ribozymes. PLoS Comput. Biol. 5(12):e1000620
- Chen X, Denison L, Levy M, Ellington AD. (2009) Direct selection for ribozyme cleavage activity in cells RNA;15(11):2035-45
- Chen X, Li N, Ellington AD. (2007) Ribozyme catalysis of metabolism in the RNA world. (Review) Chem. Biodivers. 4(4):633-55.
- Chen X, Wang Y, Liu Q, Zhang Z, Fan C, He L. (2006) Construction of molecular logic gates with a DNA-cleaving deoxyribozyme. Angew. Chem. Int. Ed. Engl. 45(11):1759-62.
(This link is left here formating examples.)
Contact
xichen at mail dot utexas dot edu