User:Wayne G. Shreffler
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Contact Info
Wayne G. Shreffler, MD, PhD
MassGeneral Hospital for Children &
MGH, Center for Immunology and Inflammatory Diseases
Bldg. 149-13th St. Rm. 8312
Charlestown MA 02129
Links:
Education
- 1998, MD, New York University
- 1997, PhD, New York University
- 1996, MS, New York University
- 1991, BS, University of Washington
Research interests
- Mechanisms of Allergenicity
- Immune Tolerance and Food Allergy
- Mechanisms of Immediate Hypersensitivity and its Regulation
Publications
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PubMed Link
Selected Research Articles
- Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr;123(4):789-94.e20. DOI:10.1016/j.jaci.2008.12.1128 |
- Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan;123(1):43-52.e7. DOI:10.1016/j.jaci.2008.09.051 |
- Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar;121(3):737-743.e10. DOI:10.1016/j.jaci.2007.11.039 |
- Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15;177(6):3677-85. DOI:10.4049/jimmunol.177.6.3677 |
- Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct;116(4):893-9. DOI:10.1016/j.jaci.2005.06.033 |
- Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr;113(4):776-82. DOI:10.1016/j.jaci.2003.12.588 |
Selected Review Articles
- Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009;524:259-72. DOI:10.1007/978-1-59745-450-6_19 |
- Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb;123(2):352-3. DOI:10.1016/j.jaci.2008.12.1119 |
- Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov;101(5):544-9. DOI:10.1016/S1081-1206(10)60295-5 |
- Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun;121(6):1311-20; quiz 1321-2. DOI:10.1016/j.jaci.2008.04.023 |
- Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):226-33. DOI:10.1097/01.all.0000225165.83144.2f |
