User:Veit-Simon Eckle

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Lebenslauf

Dr. Veit-Simon Eckle

Waldhörnlestr. 22
D-72072 Tübingen
Tel. ++49-7071/29 8 11 59
Fax ++49-7071/29 2 50 73

Research Interests:

My research focuses on the effects of volatile and intravenous anesthetics on GABA(A) and glycine receptor-mediated neurotransmission in the spinal ventral horn. This specific area of the spinal cord seems to play a key role in providing anesthetic-induced immobility. Organotypic slice cultures are well established in our lab and serve as a model for pharmacologic studies in intact neuronal networks.


Residency: Department of Anesthesiology, University of Tübingen

Department of Anesthesiology, Klinikum rechts der Isar, Munich
Department of Anesthesiology, Brüderkrankenhaus Trier

Fellowship: Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, Todorovic Lab) and Pharmacology (Prof. E. Perez Reyes Perez-Reyes Lab), University of Virginia, Charlottesville, Virginia, USA
Awards: 3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the DGAI, Congress of Anesthesiology and Intensive Care Medicine, September 2012

WAKWIN Mentee, German Society for Anaesthesiology and Intensive Care, 2010
Resident Travel Award, SNACC Meeting, Orlando 2008

Patent: link Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
Memberships: German Society for Anaesthesiology and Intensive Care
European Society of Anaesthesiology
Associate Faculty Member of the Faculty of 1000 Medicine

Selected Publications:

  • Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E. Mechanisms by which a CACNA1H mutation found in epilepsy patients increase seizure susceptibility. J Physiol. 2013 Nov 25. PubMed
  • Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013 Dec 2. PubMed
  • Eckle VS, Antkowiak B. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. Neuroscience. 2013 Dec 3;253:165-71. PubMed
  • Eckle VS, Hauser S, Drexler B, Antkowiak B, Grasshoff C. Opposing actions of sevoflurane on GABAergic and glycinergic synaptic inhibition in the spinal ventral horn. PLoS One. 2013;8(4):e60286. PubMed
  • Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 PubMed
  • Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. PubMed
  • Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. PubMed
  • Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. PubMed
  • Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. PubMed
  • Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. PubMed
  • Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. PubMed

Education

  • Year, PhD, Institute
  • Year, MS, Institute
  • Year, BS, Institute

Research interests

  1. Interest 1
  2. Interest 2
  3. Interest 3

Publications

  1. Goldbeter A and Koshland DE Jr. . pmid:6947258. PubMed HubMed [Paper1]
  2. JACOB F and MONOD J. . pmid:13718526. PubMed HubMed [Paper2]
    leave a comment about a paper here

  3. Mark Ptashne. A genetic switch. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004. isbn:0879697164. [Book1]
All Medline abstracts: PubMed HubMed

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