User:Veit-Simon Eckle

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== Lebenslauf ==
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==Contact Info==
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{|
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[[Image:OWWEmblem.png|thumb|right|Veit-Simon Eckle (an artistic interpretation)]]
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|valign="top" | [[Image:NEW.jpg|left]]
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|valign="top" | [mailto:veit-simon.eckle@uni-tuebingen.de Dr.&nbsp;Veit-Simon&nbsp;Eckle]<br>
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Waldhörnlestr.&nbsp;22<br>
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D-72072&nbsp;Tübingen<br>
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Tel.&nbsp;++49-7071/29&nbsp;8&nbsp;11&nbsp;59<br>
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Fax&nbsp;++49-7071/29&nbsp;2&nbsp;50&nbsp;73<br>
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*Veit-Simon Eckle
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|}
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*Eberhard-Karls-University Tübingen
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*Address 1
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*Address 2
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*City, State, Country etc.
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*[[Special:Emailuser/Veit-Simon Eckle|Email me through OpenWetWare]]
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I work in the [[Your Lab]] at XYZ University.  I learned about [[OpenWetWare]] from colleagues, and I've joined because for fun.
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==== Research Interests:====
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==Education==
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My research focuses on the effects of volatile and intravenous anesthetics on GABA(A) and glycine receptor-mediated neurotransmission in the spinal ventral horn. This specific area of the spinal cord seems to play a key role in providing anesthetic-induced immobility. Organotypic slice cultures are well established in our lab and serve as a model for pharmacologic studies in intact neuronal networks.
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<!--Include info about your educational background-->
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* Year, PhD, Institute
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* Year, MS, Institute
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* Year, BS, Institute
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==Research interests==
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:SpinalCord |Spinale Mechanismen der Anästhesie]]
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<!-- Feel free to add brief descriptions to your research interests as well -->
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:Alternativ |Alternative Wirksamkeits-Testung von Botulinum Toxin B an Nerven-Muskel-Zellkulturen in vitro]]
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# Interest 1
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*[[Experimental_Anaesthesiology_Antkowiak_Lab:Ballon |Intrajugulärer Ballon-Katheter zur Prävention von Luftembolie]]
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# Interest 2
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# Interest 3
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==Publications==
 
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<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
 
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<biblio>
 
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#Paper1 pmid=6947258
 
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#Paper2 pmid=13718526
 
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// leave a comment about a paper here
 
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#Book1 isbn=0879697164
 
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</biblio>
 
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==Useful links==
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{|
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*[[OpenWetWare:Welcome|Introductory tutorial]]
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|-
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*[[Help|OpenWetWare help pages]]
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| valign="top" |'''Residency:'''
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|valign="top" | [http://www.medizin.uni-tuebingen.de/Patienten/Kliniken/Anaesthesiologie+und+Intensivmedizin.html Department of Anesthesiology], [http://www.uni-tuebingen.de University of Tübingen]<br>
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[http://www.mri.tum.de/anaesthesie Department of Anesthesiology], [http://www.med.tum.de/ Klinikum rechts der Isar], Munich<br>
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[http://www.bk-trier.de/bk_trier/Medizin-Pflege/fachabteilungen/anaesthesie/index.php Department of Anesthesiology], [http://www.bk-trier.de/bk_trier/index.php Brüderkrankenhaus Trier]<br>
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|-
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| valign="top" | '''Fellowship:'''
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|valign="top" | Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, [http://www.medicine.virginia.edu/clinical/departments/anesthesiology/research/slobodan-todorovic.html Todorovic Lab]) and Pharmacology (Prof. E. Perez Reyes [http://people.virginia.edu/~ebp8n/ Perez-Reyes Lab]), University of Virginia, Charlottesville, Virginia, USA<br> 
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|-
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| valign="top" | '''Awards: '''
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| valign="top" |3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the [http://www.dgai.de/ DGAI], Congress of Anesthesiology and Intensive Care Medicine, September 2012<br>
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[http://www.wakwin.de/tiki-index.php WAKWIN] Mentee, [http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care], 2010<br>
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Resident Travel Award, [http://www.snacc.org/ SNACC] Meeting, Orlando 2008
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|-
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| valign="top" | '''Patent: '''
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| valign="top" | [http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013004739&recNum=273&docAn=EP2012063023&queryString=%28IC/a61m%29%20&maxRec=34094 link] Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
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|-
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| valign="top" | '''Memberships: '''
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| valign="top" |[http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care]<br>[http://www.euroanaesthesia.org/ European Society of Anaesthesiology]<br> Associate Faculty Member of the [http://f1000.com/ Faculty of 1000 Medicine]
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|}
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==== Selected Publications: ====
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* Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E. Mechanisms by which a CACNA1H mutation found in epilepsy patients increase seizure susceptibility. J Physiol. 2013 Nov 25. [http://www.ncbi.nlm.nih.gov/pubmed/24277868 PubMed]
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* Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013 Dec 2. [http://www.ncbi.nlm.nih.gov/pubmed/24299204 PubMed]
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* Eckle VS, Antkowiak B. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. Neuroscience. 2013 Dec 3;253:165-71. [http://www.ncbi.nlm.nih.gov/pubmed/23994185 PubMed]
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* Eckle VS, Hauser S, Drexler B, Antkowiak B, Grasshoff C. Opposing actions of sevoflurane on GABAergic and glycinergic synaptic inhibition in the spinal ventral horn. PLoS One. 2013;8(4):e60286. [http://www.ncbi.nlm.nih.gov/pubmed/23565218 PubMed]
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* Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 [http://www.ncbi.nlm.nih.gov/pubmed/22491022 PubMed]
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* Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. [http://www.ncbi.nlm.nih.gov/pubmed/22134411 PubMed]
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* Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. [http://www.ncbi.nlm.nih.gov/pubmed/21821734 PubMed]
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* Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. [http://www.ncbi.nlm.nih.gov/pubmed/20363234 PubMed]
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* Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. [http://www.ncbi.nlm.nih.gov/pubmed/19760252 PubMed]
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* Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. [http://www.ncbi.nlm.nih.gov/pubmed/19034096 PubMed]
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* Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. [http://www.ncbi.nlm.nih.gov/pubmed/14713542 PubMed]

Current revision

Lebenslauf

Dr. Veit-Simon Eckle

Waldhörnlestr. 22
D-72072 Tübingen
Tel. ++49-7071/29 8 11 59
Fax ++49-7071/29 2 50 73

Research Interests:

My research focuses on the effects of volatile and intravenous anesthetics on GABA(A) and glycine receptor-mediated neurotransmission in the spinal ventral horn. This specific area of the spinal cord seems to play a key role in providing anesthetic-induced immobility. Organotypic slice cultures are well established in our lab and serve as a model for pharmacologic studies in intact neuronal networks.


Residency: Department of Anesthesiology, University of Tübingen

Department of Anesthesiology, Klinikum rechts der Isar, Munich
Department of Anesthesiology, Brüderkrankenhaus Trier

Fellowship: Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, Todorovic Lab) and Pharmacology (Prof. E. Perez Reyes Perez-Reyes Lab), University of Virginia, Charlottesville, Virginia, USA
Awards: 3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the DGAI, Congress of Anesthesiology and Intensive Care Medicine, September 2012

WAKWIN Mentee, German Society for Anaesthesiology and Intensive Care, 2010
Resident Travel Award, SNACC Meeting, Orlando 2008

Patent: link Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
Memberships: German Society for Anaesthesiology and Intensive Care
European Society of Anaesthesiology
Associate Faculty Member of the Faculty of 1000 Medicine

Selected Publications:

  • Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E. Mechanisms by which a CACNA1H mutation found in epilepsy patients increase seizure susceptibility. J Physiol. 2013 Nov 25. PubMed
  • Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2013 Dec 2. PubMed
  • Eckle VS, Antkowiak B. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn. Neuroscience. 2013 Dec 3;253:165-71. PubMed
  • Eckle VS, Hauser S, Drexler B, Antkowiak B, Grasshoff C. Opposing actions of sevoflurane on GABAergic and glycinergic synaptic inhibition in the spinal ventral horn. PLoS One. 2013;8(4):e60286. PubMed
  • Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 PubMed
  • Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. PubMed
  • Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. PubMed
  • Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. PubMed
  • Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. PubMed
  • Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. PubMed
  • Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. PubMed
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