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Revision as of 13:56, 10 August 2006
Travis Bayer
I work on synthetic biology in the Smolke Lab at Caltech. I used to work for the Ellington Lab doing directed evolution.
Interests
- Robustness and evolvability in biology
- Engineering life with functional nucleic acids
Publications
- Tabor JJ, Bayer TS, Simpson ZB , Levy M, Ellington AD. Operons are genetic noise insulators. Submitted. 2006.
- Bayer TS, Smolke CD. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nature Biotechnology. 2005 Mar;23(3):337-43.
- Bayer TS, Booth LN, Knudsen SM, Ellington AD. Arginine-rich motifs present multiple interfaces for specific binding by RNA. RNA. 2005 Dec;11(12):1848-57.
- Kirby R, Cho EJ, Gehrke B, Bayer T, Park YS, Neikirk DP, McDevitt JT, Ellington AD. Aptamer-based sensor arrays for the detection and quantitation of proteins. Analytical Chemistry. 2004 Jul 15;76(14):4066-75.
- Cox JC, Hayhurst A, Hesselberth J, Bayer TS, Georgiou G, Ellington AD. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. Nucleic Acids Research. 2002 Oct 15;30(20):e108.
- Cox JC, Rajendran M, Riedel T, Davidson EA, Sooter LJ, Bayer TS, Schmitz-Brown M, Ellington AD. Automated acquisition of aptamer sequences. Combinatorial Chemistry and High Throughput Screening. 2002 Jun;5(4):289-99.
Bi23: Nucleic acids from origins to bioengineering
Last term I got to teach a class that I made up. It was mostly about synthetic biology, although I tried to talk about origins some. How biological function emerges, whether by human design or natural evolution, is a highly entertaining topic that draws on all kinds of science and engineering fields (and philosophy too!). Then the class evolved into a discussion of coming up with clever 'biohacks', or ways to reprogram functions of natural and synthetic genetic systems. Mostly for devious ends. I'll put up the slides and notes for it, and some of our hacks...
Nucleic acid design
Much of my work could be termed 'nucleic acid design'. The basic idea is to engineer molecules with specified functions - functions like binding, catalysis, gene regulation, or fluorescent signaling. I would like to use this space to put up some of the "design principles" that I have found helpful (hopefully this will augment what can be found in publications). There is an entire community doing this kind of work: the Ellington, Breaker, Liu, Smolke, Pierce, labs, among many others. Check out Jeff Tabor's stuff to start with.
Controlling gene expression: Riboregulators, riboswitches, RNAi...
The Wide World of Aptamers - and the people who love them...
Contact
user: tsbayer
server: caltech.edu
- Phone
626.395.2680
MC 210-41 Pasadena, CA 91125
Life imitates art, literally
LightCannon - take your own bacterial photographs!
Protocols and Recipes
Protocols
Recipes and other stuff
Fun with geography
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