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| [[Image:Tong zhou 123.jpg|thumb|right|Tong Zhou]]
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| Tong Zhou, Assistant Professor
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| Department of Physiology and Cell Biology
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| The University of Nevada School of Medicine, Reno, Nevada, 89557
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| Email: tongz@medicine.nevada.edu
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| ==Former Position==
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| * 2013 - 2016, Research Assistant Professor, Department of Medicine, The University of Arizona
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| * 2010 - 2013, Research Assistant Professor, Department of Medicine, The University of Illinois at Chicago
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| * 2006 - 2010, Postdoc, Center for Computational Biology and Bioinformatics and Section of Integrative Biology, The University of Texas at Austin
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| ==Education==
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| <!--Include info about your educational background-->
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| * 2006, PhD, Southeast University, China
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| * 2002, MS, Southeast University, China
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| * 2000, BS, Southeast University, China
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| ==Research interests==
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| <!-- Feel free to add brief descriptions to your research interests as well -->
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| # Translational and Clinical Bioinformatics
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| # Computational Genomics and Genetics
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| # Molecular Evolution
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| ==Publications==
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| <!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed -->
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| *In press
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| #Hecker L., Bime C., '''Zhou T.''', Wang T., Slepian M., and Garcia J.G., Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. ''Pulm. Circ.'', in press.
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| * 2016
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| #Qian Z., Lv J., Kelly G.T., Wang H., Zhang X., Gu W., Yin X., Wang T., and '''Zhou T.*''', Expression of nuclear factor, erythroid 2-like 2-mediated genes differentiates tuberculosis. ''Tuberculosis'', 99, 56-62, 2016. [http://dx.doi.org/doi:10.1016/j.tube.2016.04.008 doi:10.1016/j.tube.2016.04.008]
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| #Tang H., Yamamura A., Yamamura H., Song S., Fraidenburg D.R., Chen J., Gu Y., Poh N.M., '''Zhou T.''', Jiménez-Pérez L., Ayon R.J., Desai A.A., Goltzman D., Rischard F., Khalpey Z., Black S.M., Garcia J.G., Makino A., and Yuan J.X., Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. ''Am. J. Physiol. Lung Cell Mol. Physiol.'', 310, L846-859, 2016. [http://dx.doi.org/doi:10.1152/ajplung.00050.2016 doi:10.1152/ajplung.00050.2016]
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| * 2015
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| #Gu W., Gurguis C.I., Zhou J.J., Zhu Y., Ko E.A., Ko J.H., Wang T., and '''Zhou T.*''', Functional and structural consequence of rare exonic single nucleotide polymorphisms: one story, two tales. ''Genome Biol. Evol.'', 7, 2929-2940, 2015. [http://dx.doi.org/doi:10.1093/gbe/evv191 doi:10.1093/gbe/evv191]
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| #Qian Z., '''Zhou T.*''', Gurguis C.I., Xu X., Wen Q., Lv J., Fang F., Hecker L., Cress A.E., Natarajan V., Jacobson J.R., Zhang D.D., Garcia J.G., and Wang T., Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. ''Sci. Rep.'', 5, 16889, 2015. '''(*co-first author)''' [http://dx.doi.org/doi:10.1038/srep16889 doi:10.1038/srep16889]
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| #Casanova N., '''Zhou T.*''', Knox K.S., and Garcia J.G., Identifying novel biomarkers in sarcoidosis using genome-based approaches. ''Clin. Chest Med.'', 36, 621-630, 2015. '''(*co-first author)''' [http://dx.doi.org/doi:10.1016/j.ccm.2015.08.005 doi:10.1016/j.ccm.2015.08.005]
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| #Shimizu Y., Camp S.M., Sun X., '''Zhou T.''', Wang T., and Garcia J.G., Sp1-mediated nonmuscle myosin light chain kinase expression and enhanced activity in vascular endothelial growth factor–induced vascular permeability. ''Pulm. Circ.'', 5, 707–715, 2015. [http://dx.doi.org/doi:10.1086/684124 doi:10.1086/684124]
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| #Huang L.S., Berdyshev E.V., Tran J.T., Xie L., Chen J., Ebenezer D.L., Mathew B., Gorshkova I., Zhang W., Reddy S.P., Harijith A., Wang G., Feghali-Bostwick C., Noth I., Ma S.F., '''Zhou T.''', Ma W., Garcia J.G., and Natarajan V., Sphingosine 1 phosphate lyase is an endogenous suppressor of pulmonary fibrosis: Role of S1P signaling and autophagy. ''Thorax'', 70, 1138-1148, 2015. [http://dx.doi.org/doi:10.1136/thoraxjnl-2014-206684 doi:10.1136/thoraxjnl-2014-206684]
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| #Camp S.M., Ceco E., Evenoski C.L., Danilov S.M., '''Zhou T.''', Chiang E.T., Moreno-Vinasco L., Mapes B., Zhao J., Gursoy G., Brown M.E., Adyshev D.M., Siddiqui S.S., Quijada H., Sammani S., Letsiou E., Saadat L., Yousef M., Wang T., Liang J., and Garcia J.G., Unique toll-like receptor 4 activation by NAMPT/PBEF induces NFκB signaling and inflammatory lung injury. ''Sci. Rep.'', 5, 13135, 2015. [http://dx.doi.org/doi:10.1038/srep13135 doi:10.1038/srep13135]
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| #Wang R., Gurguis C.I., Gu W., Ko E.A., Lim I., Bang H., '''Zhou T.''', and Ko J.H., Ion channel gene expression predicts survival in glioma patients. ''Sci. Rep.'', 5, 11593, 2015. [http://dx.doi.org/doi:10.1038/srep11593 doi: 10.1038/srep11593]
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| #'''Zhou T.''', Wang T.*, and Garcia J.G.N.*, A nonmuscle myosin light chain kinase–dependent gene signature in peripheral blood mononuclear cells is linked to human asthma severity and exacerbation status. ''Pulm. Circ.'', 5, 335-338, 2015. (*co-corresponding author) [http://dx.doi.org/10.1086/680357 doi: 10.1086/680357]
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| #Wang T., '''Zhou T.*''', Saadat L., and Garcia J.G.N., A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure. ''Eur. J. Hum. Genet.'', 23, 874–876, 2015. '''(*co-first author)''' [http://dx.doi.org/10.1038/ejhg.2014.201 doi: 10.1038/ejhg.2014.201]
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| #Letsiou E., Sammani S., Zhang W., '''Zhou T.''', Quijada H., Moreno-Vinasco L., Dudek S.M., and Garcia J.G., Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding. ''Am. J. Respir. Cell Mol. Biol.'', 52, 193-204, 2015. [http://dx.doi.org/10.1165/rcmb.2013-0347OC doi: 10.1165/rcmb.2013-0347OC]
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| * 2014
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| #Gu W., Xu Y., Xie X., Wang T., Ko J.H., and '''Zhou T.*''', The role of RNA structure at 5’-untranslated region in microRNA-mediated gene regulation. ''RNA'', 20, 1369-1375, 2014. [http://dx.doi.org/10.1261/rna.044792.114 doi: 10.1261/rna.044792.114]
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| #Ko J.H., Gu W., Lim I., '''Zhou T.*''', and Bang H., Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. ''PLoS ONE'', 9, e110094. '''(*co-corresponding author)''' [http://dx.doi.org/10.1371/journal.pone.0110094 doi: 10.1371/journal.pone.0110094]
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| #'''Zhou T.''' and Wang T., A novel approach to investigate functional exonic SNPs associated with lung diseases at post-transcriptional stage. ''Int. J. Respir. Pulm. Med.'', 1, 002e, 2014. '''Invited editorial'''
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| #'''Zhou T.''', Wang T.*, and Garcia J.G.N., Expression of nicotinamide phosphoribosyltransferase-influenced genes predicts recurrence-free survival in lung and breast cancers. ''Sci. Rep.'', 4, 6107, 2014. (*co-first author) [http://dx.doi.org/10.1038/srep06107 doi: 10.1038/srep06107]
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| #Gu W., Li M., Xu Y., Wang T., Ko J.H., and '''Zhou T.*''', The impact of RNA structure on coding sequence evolution in both bacteria and eukaryotes. ''BMC Evol. Biol.'', 14, 87, 2014. [http://dx.doi.org/10.1186/1471-2148-14-87 doi: 10.1186/1471-2148-14-87] '''Highly accessed'''
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| #'''Zhou T.''', Wang T.*, and Garcia J.G.N. Genes influenced by the non-muscle isoform of myosin light chain kinase impact human cancer prognosis. ''PLoS ONE'', 9, e94325, 2014. (*co-first author) [http://dx.doi.org/10.1371/journal.pone.0094325 doi: 10.1371/journal.pone.0094325]
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| #Ko J.H., Gu W., Lim I., Bang H., Ko E.A., and '''Zhou T.*''', Ion channel gene expression in lung adenocarcinoma: potential role in prognosis and diagnosis. ''PLoS ONE'', 9, e86569, 2014. [http://dx.doi.org/10.1371/journal.pone.0086569 doi: 10.1371/journal.pone.0086569]
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| #Huang L.S., Mathew B., Li H., Zhao Y., Ma S.F., Noth I., Reddy S.P., Harijith A., Usatyuk P.V., Berdyshev E.V., Kaminski N., '''Zhou T.''', Zhang W., Zhang Y., Rehman J., Kotha S.R., Gurney T.O., Parinandi N.L., Lussier Y.A., Garcia J.G., and Natarajan V., The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. ''Am. J. Respir. Crit. Care Med.'', 189, 1402-1415, 2014. [http://dx.doi.org/10.1164/rccm.201310-1917OC doi: 10.1164/rccm.201310-1917OC]
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| #Wang T., Moreno-Vinasco L., Ma S.F., '''Zhou T.''', Shimizu Y., Sammani S., Epshtein Y., Watterson D.M., Dudek S.M., and Garcia J.G., Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation. ''Am. J Respir. Cell Mol. Biol.'', 50, 1129-1135, 2014. [http://dx.doi.org/10.1165/rcmb.2013-0434OC doi: 10.1165/rcmb.2013-0434OC]
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| #Abraham A., Karathedath S., Kumaraswamy V., Jayavelu A.K., M S., Srivastava V.M., Zhang W., '''Zhou T.''', George B., Srivastava A., Mathews V., and Balasubramanian P., Novel NPM1 mutation in the 3'-untranslated region identified in two patients with acute myeloid leukemia. ''Leuk. Lymphoma'', 55, 1421-1424, 2014. [http://dx.doi.org/10.3109/10428194.2013.838235 doi: 10.3109/10428194.2013.838235]
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| * 2013
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| #Ko J.H., Ko E.A., Gu W., Lim I., Bang H., and '''Zhou T.*''', Expression profiling of ion channel genes predicts clinical outcome in breast cancer. ''Mol. Cancer'', 12, 106, 2013. [http://dx.doi.org/10.1186/1476-4598-12-106 doi: 10.1186/1476-4598-12-106]
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| #Sun X. , Dr. Ma S.F., Wade M.S., Acosta-Herrera M., Villar J., Pino-Yanes M., '''Zhou T.''', Liu B., Belvitch P., Moitra J., Han Y.J., Machado R., Noth I., Natarajan V., Dudek S.M., Jacobson J.R., Flores C., and Garcia J.G.N., Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. ''Am. J. Physiol. Lung Cell Mol. Physiol.'', 305, L467-L477, 2013. [http://dx.doi.org/10.1152/ajplung.00010.2013 doi: 10.1152/ajplung.00010.2013]
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| #Zhang W., '''Zhou T.''', Ma S.F., Machado R.F., Bhorade S.M., and Garcia J.G.N., MicroRNAs implicated in dysregulation of gene expression following human lung transplantation. ''Transl. Respir. Med.'', 1, 12, 2013. [http://dx.doi.org/10.1186/2213-0802-1-12 doi: 10.1186/2213-0802-1-12]
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| #Mathew B., Jacobson J.R., Siegler J.H., Moitra J., Blasco M., Xie L.S., Unzueta C., '''Zhou T.''', Evenoski C., Al-Sakka M., Sharma R., Huey B., Bulent A., Smith B., Sundararajan J., Reddy N.M., Reddy S.P., Dudek S.M., Natarajan V., Weichselbaum R.R., and Garcia J.G.N., Role of MIF in age-related susceptibility to radiation lung injury via Nrf2 and antioxidant regulation. ''Am. J. Respir. Cell Mol Biol.'', 49, 269-278, 2013. [http://dx.doi.org/10.1165/rcmb.2012-0291OC doi: 10.1165/rcmb.2012-0291OC]
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| #Gu W., Wang X., Zhai C., '''Zhou T.*''', Xie X., Biological basis of miRNA action when their targets are located in human protein coding region. ''PLoS ONE'', 8, e63403, 2013. '''(*co-corresponding author)''' [http://dx.doi.org/10.1371/journal.pone.0063403 doi: 10.1371/journal.pone.0063403]
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| #Huang L.S., Berdyshev E., Mathew B., Fu P., Gorshkova I.A., He D., Ma W., Noth I., Ma S.F., Pendyala S., Reddy S.P., '''Zhou T.''', Zhang W., Garzon S.A., Garcia J.G.N., and Natarajan V. Targeting Sphingosine Kinase 1 attenuates bleomycin-induced pulmonary fibrosis. ''FASEB J.'', 27, 1749-1760, 2013. [http://dx.doi.org/10.1096/fj.12-219634 doi: 10.1096/fj.12-219634]
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| * 2012
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| #Gu W., Wang X., Zhai C., Xie X., and '''Zhou T.*''', Selection on synonymous sites for increased accessibility around miRNA binding sites in plants. ''Mol. Biol. Evol.'', 29, 3037-3044, 2012. [http://dx.doi.org/10.1093/molbev/mss109 doi: 10.1093/molbev/mss109]
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| #Gu W., Wang X., Zhai C., Xie X., Parinandi G., and '''Zhou T.*''', Translation efficiency in upstream region of microRNA targets in Arabidopsis thaliana. ''Evol. Bioinform.'', 8, 565-574, 2012. [http://dx.doi.org/10.4137/EBO.S10362 doi: 10.4137/EBO.S10362]
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| #'''Zhou T.''', Ko E.A.*, Gu W., Lim I., Bang H., and Ko J.H., Non-silent story on synonymous sites in voltage-gated ion channel genes. ''PLoS ONE'', 7, e48541, 2012. (*co-first author) [http://dx.doi.org/10.1371/journal.pone.0048541 doi: 10.1371/journal.pone.0048541]
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| #'''Zhou T.''', Zhang W.*, Sweiss N.J., Chen E.S., Moller D.R., Knox K.S., Ma S.F., Wade M.S., Noth I., Machado R.F., and Garcia J.G.N., Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis. ''PLoS ONE'', 7, e44818, 2012. (*co-first author) [http://dx.doi.org/10.1371/journal.pone.0044818 doi: 10.1371/journal.pone.0044818]
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| #Pitroda S.P., '''Zhou T.*''', Sweis R.F., Filippo M., Labay E., Beckett M.A., Mauceri H.J., Liang H., Darga T.E., Perakis S., Khan S.A., Sutton H.G., Zhang W., Khodarev N.N., Garcia J.G.N., and Weichselbaum R.R., Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. ''PLoS ONE'', 7, e46104, 2012. '''(*co-first author)''' [http://dx.doi.org/10.1371/journal.pone.0046104 doi: 10.1371/journal.pone.0046104]
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| #Sun X., Singleton P.A., Letsiou E., Zhao J., Belvitch P., Sammani S., Chiang E.T., Moreno-Vinasco L., Wade M.S., '''Zhou T.''', Liu B., Parastatidis I., Thomson L., Ischiropoulos H., Natarajan V., Jacobson J.R., Machado R.F., Dudek S.M., and Garcia J.G., Sphingosine-1-phosphate receptor 3 is a novel biomarker in acute lung injury. ''Am. J. Respir. Cell Mol. Biol.'', 47, 628-636, 2012. [http://dx.doi.org/10.1165/rcmb.2012-0048OC doi: 10.1165/rcmb.2012-0048OC]
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| #Frank K.M., '''Zhou T.''', Moreno-Vinasco L., Hollett B., Garcia J.G.N., and Wardenburg J.B., Host response signature to Staphylococcus aureus α-hemolysin implicates pulmonary TH17 response. ''Infection and Immunity'', 80, 3161-3169, 2012. [http://dx.doi.org/10.1128/IAI.00191-12 doi: 10.1128/IAI.00191-12]
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| #Desai A.A., '''Zhou T.''', Ahmad H., Zhang W., Mu W., Trevino S., Wade M.S., Raghavachari N., Kato G.J., Peters-Lawrence M., Thiruvoipati T., Turner K., Artz N., Huang Y., Patel A.R., Yuan J.X., Gordeuk V.R., Lang R.M., Garcia J.G.N., and Machado R.F., A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. ''Am. J. Respir. Crit. Care. Med.'', 186, 359-368, 2012. [http://dx.doi.org/10.1164/rccm.201201-0057OC doi: 10.1164/rccm.201201-0057OC]
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| #Gorshkova I., '''Zhou T.''', Mathew B., Jacobson J.R., Takekoshi D., Bhattacharya P., Smith B., Aydogan B., Weichselbaum R.R., Natarajan V., Garcia J.G., and Berdyshev E.V., Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. ''J. Lipid Res.'', 53, 1553-1568, 2012. [http://dx.doi.org/10.1194/jlr.M026039 doi: 10.1194/jlr.M026039]
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| #Mekontso Dessap A., Voiriot G., '''Zhou T.''', Marcos E., Dudek S.M., Jacobson J.R., Machado R., Adnot S., Brochard L., Maitre B., and Garcia J.G., Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury. ''Am. J. Respir. Cell Mol. Biol.'', 46, 541-550, 2012. [http://dx.doi.org/10.1165/rcmb.2011-0306OC doi: 10.1165/rcmb.2011-0306OC]
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| * 2011
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| #Mathew B., Jacobson J.R., Berdyshev E., Huang Y., Sun X., Zhao Y., Gerhold L.M., Siegler J., Evenoski C., Wang T., '''Zhou T.''', Zaidi R., Moreno-Vinasco L., Bittman R., Chen C.T., Lariviere P.J., Sammani S., Lussier Y.A., Dudek S.M., Natarajan V., Weichselbaum R.R., and Garcia J.G., Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. ''FASEB J.'', 25, 3388-3400, 2011. [http://dx.doi.org/10.1096/fj.11-183970 doi: 10.1096/fj.11-183970]
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| #Ma S.F., Xie L., Pino-Yanes M., Sammani S., Wade M.S., Letsiou E., Siegler J., Wang T., Infusino G., Kittles R.A., Flores C., '''Zhou T.''', Prabhakar B.S., Moreno-Vinasco L., Villar J., Jacobson J.R., Dudek S.M., and Garcia J.G., Type 2 deiodinase and host responses of sepsis and acute lung injury. ''Am. J. Respir. Cell Mol. Biol.'', 45, 1203-1211, 2011. [http://dx.doi.org/10.1165/rcmb.2011-0179OC doi: 10.1165/rcmb.2011-0179OC]
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| #Sammani S., Park K.S., Zaidi S.R., Mathew B., Wang T., Huang Y., '''Zhou T.''', Lussier Y.A., Husain A.N., Moreno-Vinasco L., Vigneswaran W.T., and Garcia J.G., A sphingosine 1-phosphate 1 receptor agonist modulates brain death-induced neurogenic pulmonary injury. ''Am. J. Respir. Cell Mol. Biol.'', 45, 1022-1027, 2011. [http://dx.doi.org/10.1165/rcmb.2010-0267OC doi: 10.1165/rcmb.2010-0267OC]
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| #Ramsey D.C., Scherrer M.P., '''Zhou T.''', and Wilke C.O., The relationship between relative solvent accessibility and evolutionary rate in protein evolution. ''Genetics'', 188, 479-488, 2011. [http://dx.doi.org/10.1534/genetics.111.128025 doi: 10.1534/genetics.111.128025]
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| #'''Zhou T.''' and Wilke C.O., Reduced stability of mRNA secondary-structure near the translation-initiation site in dsDNA viruses. ''BMC Evol. Biol.'', 11, 59, 2011. [http://dx.doi.org/10.1186/1471-2148-11-59 doi: 10.1186/1471-2148-11-59]
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| #'''Zhou T.''', Garcia J.G.N., and Zhang W., Integrating microRNAs into a system biology approach to acute lung injury. ''Transl. Res.'', 157, 180-190, 2011. [http://dx.doi.org/10.1016/j.trsl.2011.01.010 doi: 10.1016/j.trsl.2011.01.010] '''Featured in [http://www.elsevier.com//about//press-releases//research-and-journals//micrornas-a-potential-new-frontier-for-medicine Elsevier]'''
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| * 2010
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| #Gu W., '''Zhou T.*''', and Wilke C.O., A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes. ''PLoS Comput. Biol.'', 6, e1000664, 2010. '''(*co-first author)''' [http://dx.doi.org/10.1371/journal.pcbi.1000664 doi: 10.1371/journal.pcbi.1000664] '''Featured in [http://www.genomeweb.com//node/933145?hq_e=el&hq_m=612914&hq_l=5&hq_v=77f63d GenomeWeb Daily Scan]'''
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| #Stark A.L., Zhang W., '''Zhou T.''', O’Donnell P.H., Beiswanger C.M.,Huang R.S., Cox N.J., and Dolan M.E., Population differences in rate of proliferation of international HapMap cell lines. ''Am. J. Hum. Genet.'', 87, 829-833, 2010. [http://dx.doi.org/10.1016/j.ajhg.2010.10.018 doi: 10.1016/j.ajhg.2010.10.018]
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| #Lee Y., '''Zhou T.''', Tartaglia G.G., Vendruscolo M., and Wilke C.O., Translationally optimal codons associate with aggregation-prone sites in proteins. ''Proteomics'', 10, 4163-4171, 2010. [http://dx.doi.org/10.1002/pmic.201000229 doi: 10.1002/pmic.201000229]
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| #'''Zhou T.''', Gu W., and Wilke C.O., Detecting positive and purifying selection at synonymous sites in yeast and worm. ''Mol. Biol. Evol.'', 27, 1912-1922, 2010. [http://dx.doi.org/10.1093/molbev/msq077 doi: 10.1093/molbev/msq077]
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| #Novella I.S., Presloid J.B., '''Zhou T.''', Smith-Tsurkan S.D., Ebendick-Corpus B.E., Dutta R.N., Lust K.L., and Wilke C.O., Genomic evolution of vesicular stomatitis virus strains with differences in adaptability. ''J. Virol.'', 84, 4960-4968, 2010. [http://dx.doi.org/10.1128/JVI.00710-09 doi: 10.1128/JVI.00710-09]
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| * Before 2010
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| #'''Zhou T.''', Weems M., and Wilke C.O., Translationally optimal codons associate with structurally sensitive sites in protein. ''Mol. Biol. Evol.'', 26, 1571-1580, 2009. [http://dx.doi.org/10.1093/molbev/msp070 doi: 10.1093/molbev/msp070]
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| #'''Zhou T.''', Enyeart P.J., and Wilke C.O., Detecting clusters of mutations. ''PLoS ONE'', 3, e3765, 2008. [http://dx.doi.org/10.1371/journal.pone.0003765 doi: 10.1371/journal.pone.0003765]
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| #'''Zhou T.''', Drummond D.A., and Wilke C.O., Contact density affects protein evolutionary rate from bacteria to animals. ''J. Mol. Evol.'', 66, 395-404, 2008. [http://dx.doi.org/10.1007/s00239-008-9094-4 doi: 10.1007/s00239-008-9094-4]
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| #'''Zhou T.''', Weng J., Sun X., and Lu Z., Support vector machine for classification of recombination hotspots and coldspots in Saccharomyces cerevisiae based on codon composition. ''BMC Bioinformatics'', 7, 223, 2006. [http://dx.doi.org/10.1186/1471-2105-7-223 doi: 10.1186/1471-2105-7-223]
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| #'''Zhou T.''', Sun X., and Lu Z., Synonymous codon usage in environmental chlamydia UWE25 reflects an evolutional divergence from pathogenic chlamydiae. ''Gene'', 368, 117-125, 2006. [http://dx.doi.org/10.1016/j.gene.2005.10.035 doi: 10.1016/j.gene.2005.10.035]
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| #'''Zhou T.''', Gu W., Ma J., Sun X., and Lu Z., Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses. ''Biosystems'', 81, 77-86, 2005. [http://dx.doi.org/10.1016/j.biosystems.2005.03.002 doi: 10.1016/j.biosystems.2005.03.002]
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| #'''Zhou T.''', Lu Z., and Sun X., The correlation between recombination rate and codon bias in yeast mainly results from mutational bias associated with recombination rather than Hill-Robertson interference. ''Conf. Proc. IEEE Eng. Med. Biol. Soc.'', 5, 4787-4790, 2005. [http://dx.doi.org/10.1109/IEMBS.2005.1615542 doi: 10.1109/IEMBS.2005.1615542]
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| #Song X., '''Zhou T.''', and Zhang H., Support vector regression estimation based on non-uniform lost function. ''Conf. Proc. IEEE Eng. Med. Biol. Soc.'', 2, 1127-1130, 2005. [http://dx.doi.org/10.1109/IEMBS.2005.1616619 doi: 10.1109/IEMBS.2005.1616619]
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| #Gu W., '''Zhou T.''', Ma J., Sun X., and Lu Z., Analysis of synonymous codon usage in SARS coronavirus and other viruses in the Nidovirales. ''Virus Res.'', 101, 155-161, 2004. [http://dx.doi.org/10.1016/j.virusres.2004.01.006 doi: 10.1016/j.virusres.2004.01.006]
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| #Gu W., '''Zhou T.''', Ma J., Sun X., and Lu Z., The relationship between synonymous codon usage and protein structure in Escherichia coli and Homo sapiens. ''Biosystems'', 73, 89-97, 2004. [http://dx.doi.org/10.1016/j.biosystems.2003.10.001 doi: 10.1016/j.biosystems.2003.10.001]
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| #Gu W., '''Zhou T.''', Ma J., Sun X., and Lu Z., Folding type specific secondary structure propensities of synonymous codons. ''IEEE T. Nanobiosci.'', 2, 150-157, 2003. [http://dx.doi.org/10.1109/TNB.2003.817024 doi: 10.1109/TNB.2003.817024 ]
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| #Ma J., '''Zhou T.''', Gu W., Sun X., and Lu Z., Cluster analysis of the codon use frequency of MHC genes from different species. ''Biosystems'', 65, 199-207, 2002. [http://dx.doi.org/10.1016/S0303-2647(02)00016-3 doi: 10.1016/S0303-2647(02)00016-3]
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