- develop and apply statistical models to estimate genetic architectures and predict multiple traits jointly;
- collaborate with researchers, farmers and citizens to breed new varieties of cultivated plants in a sustainable manner;
- promote reproducibility with free/open tools to facilitate traceability, transparency, and collaborative improvement.
Since January 2014, I am a research scientist (Chargé de Rercherche, CR) at the INRA, in the team "Diversity, Adaptation and Breeding of Grapevine" (DAAV) of the lab "Genetic Improvement and Adaptation of Mediterranean and Tropical Plants" (UMR AGAP), part of the INRA division "Plant Biology and Breeding" (Biologie et Amélioration des Plantes, BAP), based in the INRA center of Montpellier. I have been recruited on the profile "Quantitative genetics and genomics" (topic "Genomic selection and grapevine genetics").
- INRA, UMR AGAP - bâtiment 21 - 4e étage, 2 place Viala, 34070 Montpellier, France
Until December 2013, I was doing a postdoc with Matthew Stephens at the University of Chicago.
- University of Chicago, Department of Human Genetics, CLSC, 5801 S Ellis Ave, Chicago, IL 60637, USA
I learned about this website, OpenWetWare, thanks to friends participating in iGEM a few years ago. I joined it because it seems to be a great project, and I like the idea of promoting more openness in science.
- 2007-2010, PhD in bioinformatics and evolutionary genomics, Université Paris Diderot (FDV); advisors: H. Quesneville and C. Feuillet
- 2006-2007, MS, interdisciplinary, Université Paris Diderot (AIV)
- 2003-2007, BS+MS in engineering and life sciences, lycée Sainte Geneviève and AgroParisTech
See also my online CV.
All my publications are listed below as well as on my CiteULike account, and can be retrieved via ProdINRA, Google Scholar and Pubmed. When possible (that is, in agreement with my co-authors), my preprints are available online (upon submission, that is before publication, for instance on arXiv).
- 15) Twenty tips for high-school students engaging in research with scientists.
- Andújar, Campderrós, García, Marino, Mas, Narbona, Pérez, Rodrigo, Velásquez, Vilà, Laguna, Flutre, Bonnefond, Sescousse, Riboli-Sasco.
- Frontiers for Young Minds, 2015 (DOI, Open Acess: CC BY 3.0)
- 14) The Genotype-Tissue expression (GTEx) pilot analysis, multi-tissue gene regulation in humans.
- The GTEx Consortium
- Science, 2015 (DOI)
- 13) The Genotype-Tissue Expression (GTEx) project.
- Lonsdale, ..., Flutre T, ..., et al.
- Nature Genetics, 2013 (DOI, Open Access: CC BY-NC-SA 3.0)
- 12) A statistical framework for joint eQTL analysis in multiple tissues.
- Flutre T*, Wen X*, Pritchard J, Stephens M.
- PLoS Genetics, 2013 (arXiv, DOI, Open Access: CC BY 2.5)
- eQtlBma (free software under GPL)
- 11) Transposable element annotation in completely sequenced eukaryote genomes.
- Flutre T, Permal E, Quesneville H.
- Plant Transposable Elements: Impact on Genome Structure and Function, Springer, 2012 (DOI, Restricted Access)
- 10) The ABO blood group is a trans-species polymorphism in primates.
- Ségurel L*, Thompson E E*, Flutre T, Lovstad J, Venkat A, Margulis S W, Moyse J, Ross S, Gamble K, Sella G, Ober C, Przeworski M.
- Proceedings of the National Academy of Sciences, 2012 (arXiv, DOI, Open Access after 6 months)
- 9) Roadmap for annotating transposable elements in eukaryote genomes.
- Permal E, Flutre T, Quesneville H.
- Mobile Genetics Elements: Protocols and Genomic Applications, Springer, 2012 (DOI, Restricted Access)
- 8) TriAnnot, a versatile and high performance pipeline for the automated annotation of plant genomes.
- Leroy P, Guilhot N, Sakai H, Bernard A, Choulet F, Theil S, Reboux S, Amano N, Flutre T, Pelegrin C, Ohyanagi H, Seidel M, Giacomoni F, Reichstadt M, Alaux M, Gicquello E, Legeai F, Cerutti L, Numa H, Tanaka T, Mayer K, Itoh T, Quesneville H, Feuillet C.
- Frontiers in Plant Science, 2012 (DOI, Open Access: CC BY-NC 3.0)
- 7) Pilot scheme for misconduct database.
- Flutre T, Julou T, Riboli-Sasco L, Ribrault C.
- Nature, 2011 (DOI, Open Access)
- 6) In search of lost trajectories, recovering the diversification of transposable elements.
- Flutre T, Permal E, Quesneville H.
- Mobile Genetics Elements, 2011 (DOI, Open Access)
- 5) Considering transposable element diversification in de novo annotation approaches.
- Flutre T, Duprat E, Feuillet C, Quesneville H.
- PLoS One, 2011 (DOI, Open Access: CC BY 2.5)
- REPET (free software under CeCILL)
- 4) L'annotation des éléments transposables par la compréhension de leur diversification.
- Flutre T, advised by Quesneville H and Feuillet C.
- PhD thesis, Université Paris Diderot, 2010 (downloadable on TEL and DART-Europe)
- 3) Scientific Red Cards - a collaborative website for better communication between scientists and institutions about misconduct.
- Flutre T, Julou T, Riboli-Sasco L, Ribrault C.
- European Science Editing, 2010 (URL, Open Access)
- 2) Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements.
- d'Alençon E, Sezutsu H, Legeai F, Permal E, Bernard-Samain S, Gimenez S, Gagneur C, Cousserans F, Shimomura M, Brun-Barale A, Flutre T, Couloux A, East P, Gordon K, Mita K, Quesneville H, Fournier P, Feyereisen R.
- Proceedings of the National Academy of Sciences, 2010 (DOI, Open Access)
- 1) Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita.
- Abad P, Gouzy J, Aury JM, Castagnone-Sereno P, Danchin EG, Deleury E, Perfus-Barbeoch L, Anthouard V, Artiguenave F, Blok VC, Caillaud MC, Coutinho PM, Dasilva C, De Luca F, Deau F, Esquibet M, Flutre T, Goldstone JV, Hamamouch N, Hewezi T, Jaillon O, Jubin C, Leonetti P, Magliano M, Maier TR, Markov GV, McVeigh P, Pesole G, Poulain J, Robinson-Rechavi M, Sallet E, Ségurens B, Steinbach D, Tytgat T, Ugarte E, van Ghelder C, Veronico P, Baum TJ, Blaxter M, Bleve-Zacheo T, Davis EL, Ewbank JJ, Favery B, Grenier E, Henrissat B, Jones JT, Laudet V, Maule AG, Quesneville H, Rosso MN, Schiex T, Smant G, Weissenbach J, Wincker P.
- Nature Biotechnology, 2008 (DOI, Open Access: CC BY-NC-SA 3.0)
The french academic system requires researchers (with a PhD) to pass yet another exam to be granted the right to supervise PhD students. I still haven't done it, and thus can only officially supervise Master students:
- 05/2015-12/2015: Pierre-Etienne Alary, student from Montpellier SupAgro
- project: "QTL mapping for growth curve via stochastic differential equation"
- joint supervision with B. Fontez (Montpellier SupAgro), P. Roumet (INRA) and A. Garcia (The Plant Accelerator, Univ. of Adelaide)
- 03/2015-08/2015: Dalel Ahmed, Master APIMET (SEPMET) from Montpellier SupAgro
- project: "Analyze the genetic architectures of traits of interest in a diversity panel of cultivated grapevines"
I can however be part of the thesis committee of PhD students (once a year):
- 01/2016-12/2018: Dalel Ahmed, PhD student at INRA Corse
- project: "Genomic analysis of the impact of 2n gametes on the genetic structure and the expression of fruit quality from hybrids of triploid mandarins"
- 10/2015-09/2018: Gaëlle van Frank, PhD student at INRA Versailles (Le Moulon)
- project: "Participatory management of crop diversity and on-farm breeding for diverse wheat mixtures"
- 09/2015-08/2018: Cathy Bouffartigue, PhD student at INRA Orléans
- project: "Participatory breeding of oak and chestnut for agroforestery usage"
As an INRA researcher, I am not required to teach, but I am sometimes asked by colleagues to speak in their class, or to present in seminars:
- tutorial on multiple testing (in french)
- workshop on genomic predictions (in french, with Jacques David)
- tutorial on reproducible research
- tutorial on genotype-environment interactions (in french, with Nadine Hilgert)
- 01/2015-12/2016: grant from metaprogram SelGen from INRA for the FruitSelGen project
- topic: "Assessing genomic selection within bi-parental crosses for perennial fruit crops" (grapevine, apple, peach, apricot, cherry)
- status: investigator and coordinator (6 different INRA labs involved)
- amount: 114 k€ (no salary)
- 06/2014-05/2018: grant from CASDAR for the EDGARR project
- topic: "Exploitation De la sélection Génomique afin d’Accélérer la création de variétés Résistantes et qualitatives pour la filière viticole Rosé"
- status: investigator (coordinator is Loïc Le Cunff)
- amount: 220 k€ (no salary)
- 2013-2017: grant from metaprogram SelGen from INRA for the R2D2 project
- topic: "Network studying genetic and economic efficiency of genomic selection for about 20 animal and vegetal species"
- status: participant (coordinators are Bruno Goffinet and Stéphane Lemarié for the v1; Stéphane Lemarié, Christèle Robert-Granié and Laurence Moreau for the v2)
- amount: ? k€ (v1) and 76 k€ (v2)
- 2013-2015: grant from Agropolis Fondation for the Labo Hors Murs project
- topic: "participatory research for agricultural biodiversity"
- status: participant (coordinators are Bob Brac de la Perrière and Pascal Moity-Maizi)
- amount: ? k€
- 06/2014-05/2016: starter grant from department BAP of INRA for the SelVi project
- topic: "Genomic selection on grapevine, a feasibility study"
- status: principal investigator
- amount: 24 k€ (no salary)
- 01/2014-: research scientist at INRA
- topic: "Quantitative genetics and genomics" ("Genomic selection and grapevine genetics")
- status: civil servant (permanent position)
- amount: monthly salary of 2120 € (net)
- 11/2010-08/2013: postdoc fellowship from INRA (ASC as well as from the Mission des Relations Internationales, MRI); also the University of Chicago and the NIH (grant MH090951)
- topic: "Statistical methods for eQTL detection"
- status: postdoc
- amount: monthly salary of 1990 € (net, INRA only)
- 09/2007-10/2010: PhD fellowship from INRA (Assistant Scientifique Contractuel, ASC)
- topic: "The annotation of transposable elements through the understanding of their diversification"
- status: PhD student
- amount: monthly salary of 1560-1990 € (net)