User:Thomas Crouzier

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Contact Info

Thomas Crouzier (an artistic interpretation)

• Thomas Crouzier
• MIT
• Find me in building 56, room 367
• Email : crouzier at mit dot edu

Education

• 01/2006 – 03/2010

PhD student at the University of Montpellier (France) working on surface modification of biomaterials. Under the supervision of Pr. C. Picart. I engineered a new type of bioactive surface modification made from biocompatible polymer loaded with a growth factor. The delivery of the protein triggers the formation of bone in contact with the material. A collaboration in association with orthopedic surgeons has been established for further development.

08/2005- 01/2006 Masters in bioengineering as part of a double degree exchange program with the University of Oklahoma (USA). Under the supervision of Pr. P. McFetridge. I developed of a scaffold material for peripheral nerve and cardiovascular tissue engineering. The research gave rise to two peered reviewed articles and a Masters degree in Biological Engineering.

09/2003- 01/2006 Bioengineering student (Institute of Engineering Sciences - University of Clermont-Ferrand, France).

Research interests

Hi Everybody. I'm a postdoc in Katharina Ribbeck's lab. The lab is multidisciplinary and focused on biological hydrogels and in particular mucus and biofilms. My work is focused on the study of cell-mucin interactions, the physicochemical characterization of mucin coatings and the development of mucin-based biomaterials. I have been extracting the essential component of mucus (mucins), and am doing exploratory work to expose the potential of this molecule to be used as a building block for new biomaterials. These biomaterials can be used to better understand mucus (its biophysical properties and its biology) and for biomedical applications such as drug delivery.

1. Biomaterials
2. cell-material interactions
3. Biopolymers and biomacromolecules

Selected Publications

1. Crouzier T, Beckwitt CH, and Ribbeck K. Mucin multilayers assembled through sugar-lectin interactions. Biomacromolecules. 2012 Oct 8;13(10):3401-8. DOI:10.1021/bm301222f |
2. Crouzier T, Sailhan F, Becquart P, Guillot R, Logeart-Avramoglou D, and Picart C. The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating. Biomaterials. 2011 Oct;32(30):7543-54. DOI:10.1016/j.biomaterials.2011.06.062 |
3. Crouzier T, Fourel L, Boudou T, Albigès-Rizo C, and Picart C. Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration. Adv Mater. 2011 Mar 25;23(12):H111-8. DOI:10.1002/adma.201004637 |
4. Boudou T, Crouzier T, Nicolas C, Ren K, and Picart C. Polyelectrolyte multilayer nanofilms used as thin materials for cell mechano-sensitivity studies. Macromol Biosci. 2011 Jan 10;11(1):77-89. DOI:10.1002/mabi.201000301 |
5. Boudou T, Crouzier T, Auzély-Velty R, Glinel K, and Picart C. Internal composition versus the mechanical properties of polyelectrolyte multilayer films: the influence of chemical cross-linking. Langmuir. 2009 Dec 15;25(24):13809-19. DOI:10.1021/la9018663 |
6. Boudou T, Crouzier T, Ren K, Blin G, and Picart C. Multiple functionalities of polyelectrolyte multilayer films: new biomedical applications. Adv Mater. 2010 Jan 26;22(4):441-67. DOI:10.1002/adma.200901327 |
7. Crouzier T, Szarpak A, Boudou T, Auzély-Velty R, and Picart C. Polysaccharide-blend multilayers containing hyaluronan and heparin as a delivery system for rhBMP-2. Small. 2010 Mar 8;6(5):651-62. DOI:10.1002/smll.200901728 |
8. Crouzier T, Ren K, Nicolas C, Roy C, and Picart C. Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts. Small. 2009 Mar;5(5):598-608. DOI:10.1002/smll.200800804 |
9. Crouzier T and Picart C. Ion pairing and hydration in polyelectrolyte multilayer films containing polysaccharides. Biomacromolecules. 2009 Feb 9;10(2):433-42. DOI:10.1021/bm8012378 |
10. Crouzier T, Nimmagadda A, Nollert MU, and McFetridge PS. Modification of single walled carbon nanotube surface chemistry to improve aqueous solubility and enhance cellular interactions. Langmuir. 2008 Nov 18;24(22):13173-81. DOI:10.1021/la801999n |
11. Ren K, Crouzier T, Roy C, and Picart C. Polyelectrolyte multilayer films of controlled stiffness modulate myoblast cells differentiation. Adv Funct Mater. 2008;18(9):1378-1389. DOI:10.1002/adfm.200701297 |
12. Crouzier T, McClendon T, Tosun Z, and McFetridge PS. Inverted human umbilical arteries with tunable wall thicknesses for nerve regeneration. J Biomed Mater Res A. 2009 Jun;89(3):818-28. DOI:10.1002/jbm.a.32103 |

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