User:Steven J. Koch/MTC/April 19 2011: Difference between revisions

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* [[/GMA|What is going on in gliding assay?]]
* [[/GMA|What is going on in gliding assay?]]
** Andy video dissertation: http://openwetware.org/wiki/User:Andy_Maloney/Kinesin_%26_Microtubule_Page
* Kinesin modeling (mostly Larry)
** Kinesin modeling (mostly Larry)
** Neck linker docking
*** Neck linker docking
*** What is best way to model tension in the neck linker (chain of amino acids)
**** What is best way to model tension in the neck linker (chain of amino acids)
*** '''GROUP WORK''':  In the two-headed bound state, does neck-linker docking INCREASE or DECREASE or KEEP SAME the tension
**** '''GROUP WORK''':  In the two-headed bound state, does neck-linker docking INCREASE or DECREASE or KEEP SAME the tension
**** (A) Back head docks;  (B) Front head docks
***** (A) Back head docks;  (B) Front head docks
**** Discuss with partner and make answers for (A) and (B)
***** Discuss with partner and make answers for (A) and (B)

Revision as of 05:49, 19 April 2011

Tuesday April 19, 2011. Microtubule gliding assay / kinesin modeling

  • Apology for being sick / missing so much. Reiterate the goals of the class
    • Learn some molecular biophysics
    • More importantly: learn resources for doing molecular biophysics research (PDB, OpenWetWare, S30, Mendeley, Figshare, etc.)
  • Assignment due Tuesday April 26
  • What is going on in gliding assay?
  • Kinesin modeling (mostly Larry)
    • Neck linker docking
      • What is best way to model tension in the neck linker (chain of amino acids)
      • GROUP WORK: In the two-headed bound state, does neck-linker docking INCREASE or DECREASE or KEEP SAME the tension
        • (A) Back head docks; (B) Front head docks
        • Discuss with partner and make answers for (A) and (B)
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