User:Slokwong/Module 4: Biomaterial Engineering: Difference between revisions

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===Research Proposal===
===Research Proposal===
*'''Project Overview'''
<font color=blue>'''Project Overview'''</font>


A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.  
*A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.  


*'''Background'''
<font color=blue>'''Background'''</font>
*'''Problem and Goals'''
<font color=blue>'''Problem and Goals'''</font>
*'''Project details and methods'''
<font color=blue>'''Project details and methods'''</font>
*'''Predicted Outcomes'''
<font color=blue>'''Predicted Outcomes'''</font>


*'''Resources'''
<font color=blue>'''Resources'''</font>
1. http://web.mit.edu/newsoffice/2006/hemostasis.html
1. http://web.mit.edu/newsoffice/2006/hemostasis.html


2. '''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215.
'''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215.


''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.''  
*''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.''  


3.'''Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider.''' 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS '''103''': 5054-5059.  
2.'''Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider.''' 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS '''103''': 5054-5059.  


''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.''  
*''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.''  


4.'''Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee.''' 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation '''111''': 442-450.
3.'''Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee.''' 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation '''111''': 442-450.


''They demonstrated that self-assembling peptides can be injected and that the resulting
*''They demonstrated that self-assembling peptides can be injected and that the resulting
nanofiber microenvironments can be detected.''  
nanofiber microenvironments can be detected.''  


5.'''Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang.''' 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release '''115''': 18-25.
4.'''Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang.''' 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release '''115''': 18-25.


''Describes the structure of self-assmebling peptide nanofibers.''  
*''Describes the structure of self-assmebling peptide nanofibers.''  


6.http://www.innovitaresearch.org/news/06102501.html
5.http://www.innovitaresearch.org/news/06102501.html


''Describes self-assembling peptide nanofiber scaffolds and what they are used for.''
*''Describes self-assembling peptide nanofiber scaffolds and what they are used for.''

Revision as of 12:33, 3 May 2007

Research Proposal

Project Overview

  • A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.

Background Problem and Goals Project details and methods Predicted Outcomes

Resources 1. http://web.mit.edu/newsoffice/2006/hemostasis.html

Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So. 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2: 207-215.

  • They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.

2.Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So G. Schneider. 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS 103: 5054-5059.

  • Describes how the self-assembling peptide nanofiber scaffold was created and how it works.

3.Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee. 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111: 442-450.

  • They demonstrated that self-assembling peptides can be injected and that the resulting

nanofiber microenvironments can be detected.

4.Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang. 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release 115: 18-25.

  • Describes the structure of self-assmebling peptide nanofibers.

5.http://www.innovitaresearch.org/news/06102501.html

  • Describes self-assembling peptide nanofiber scaffolds and what they are used for.
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