User:Slokwong/Module 4: Biomaterial Engineering: Difference between revisions
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===Research Proposal=== | ===Research Proposal=== | ||
*Project Overview | *'''Project Overview''' | ||
A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it. | A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it. | ||
*Background | *'''Background''' | ||
*Problem and Goals | *'''Problem and Goals''' | ||
*Project details and methods | *'''Project details and methods''' | ||
*Predicted Outcomes | *'''Predicted Outcomes''' | ||
*Resources | *'''Resources''' | ||
http://web.mit.edu/newsoffice/2006/hemostasis.html | #http://web.mit.edu/newsoffice/2006/hemostasis.html | ||
'''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. | #'''Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So.''' 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine '''2''': 207-215. | ||
''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.'' | ''They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.'' | ||
'''Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So; G. Schneider.''' 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS '''103''': 5054-5059. | #'''Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So; G. Schneider.''' 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS '''103''': 5054-5059. | ||
''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.'' | ''Describes how the self-assembling peptide nanofiber scaffold was created and how it works.'' | ||
'''Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee.''' 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation '''111''': 442-450. | #'''Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee.''' 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation '''111''': 442-450. | ||
''They demonstrated that self-assembling peptides can be injected and that the resulting | ''They demonstrated that self-assembling peptides can be injected and that the resulting | ||
nanofiber microenvironments can be detected.'' | nanofiber microenvironments can be detected.'' | ||
'''Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang.''' 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release '''115''': 18-25. | #'''Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang.''' 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release '''115''': 18-25. | ||
''Describes the structure of self-assmebling peptide nanofibers.'' | ''Describes the structure of self-assmebling peptide nanofibers.'' | ||
http://www.innovitaresearch.org/news/06102501.html | #http://www.innovitaresearch.org/news/06102501.html | ||
''Describes self-assembling peptide nanofiber scaffolds and what they are used for.'' | ''Describes self-assembling peptide nanofiber scaffolds and what they are used for.'' | ||
Revision as of 09:38, 3 May 2007
Research Proposal
- Project Overview
A study by MIT and HKU researchers showed that some biodegradable liquids can stop bleeding in seconds. Peptides self-assemble in to a gel to seal the wound and stop the bleeding. Once the wound is healed, the cells use the gel to repair tissue. Using this concept, we propose to find a material that can target tumors and then contain them so that they can't grow or metastasize. After the tumor is contained, a variety of drugs or therapies can be applied to it to eliminate it.
- Background
- Problem and Goals
- Project details and methods
- Predicted Outcomes
- Resources
- Ellis-Behnke, R. G.; Y. Liang; D. Tay; P. Kau; G. Schneider; S. Zhang; W. Wu; K. So. 2006. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2: 207-215.
They used a self-assembling solution (NHS-1) that was prepared using a RADA16-I synthetic dry powder obtained from MIT Zhang lab. The study describes experiments testing for how the solution works. They also compared the efficiency of the NHS-1 solution with saline and cautery treated controls. They found that in all cases the NHS-1 worked better.
- Ellis-Behnke, R. G.; Y. Liang; S. You; D. Tay; S. Zhang; K. So; G. Schneider. 2006. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. PNAS 103: 5054-5059.
Describes how the self-assembling peptide nanofiber scaffold was created and how it works.
- Davis, M.; J.P. Motion; D. Narmoneva; T. Takahashi; D. Hakuno; R. Kamm; S. Zhang; R. Lee. 2005. Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Circulation 111: 442-450.
They demonstrated that self-assembling peptides can be injected and that the resulting nanofiber microenvironments can be detected.
- Nagai, Y.; L. Unsworth; S. Koutsopoulos; S. Zhang. 2006. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release 115: 18-25.
Describes the structure of self-assmebling peptide nanofibers.
Describes self-assembling peptide nanofiber scaffolds and what they are used for.
