User:Shicheng Guo

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Contact Info

Shicheng Guo (an artistic interpretation)

• Shicheng Guo, Ph.D.
• University of California at San Diego
• 9500 Gilman Drive MC 0412. La Jolla, San Diego, CA 92093-0412
• Email: scguo@ucsd.edu

Education

• 2009-2014, PhD, Genetics, School of Life Sciences, Fudan University, Shanghai, China
• 2005-2009, BS, Bio-technique, School of Life Sciences, Northeast Agricultural University,Harbin, China

Research interests

Shicheng Guo, Ph.D. (2009-2014), School of Life Sciences, Fudan University. His supervisors are Li Jin, Jiucun Wang and Momiao Xiong (Uthealth, Houston). The realm which he focus on now is computational biology and medical statistics including: manifold kinds of microarray analysis, meta-analysis, genome-wide SNP, RNA, Methylation, CNV analysis based on next generation sequencing technology. In the past three years, he had participated in series of attractive research( Yan-Huang methylome project et.al), and participated in publishing several interesting papers( Nature Biotechnology, Plos Biology et al) and two Chinese patents. Specially, in clinical field, he want to explore some high sensitive and specific diagnosis and prognosis biomarkers for some complex disease such as immune diseases, cancer. And then establish some high accuracy disease prediction models so that doctors can make more felicitous decision to his/her patients. 5 years Perl, R usage exprience under Ubuntu.

Scientific Project

• Methylation Haplotype for Non-invasive Cancer Diagnosis

Publications

1. Guo S, Yan F, Xu J, Bao Y, Zhu J, Wang X, Wu J, Li Y, Pu W, Liu Y, Jiang Z, Ma Y, Chen X, Xiong M, Jin L, and Wang J. Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). Clin Epigenetics. 2015;7(1):3. DOI:10.1186/s13148-014-0035-3 |
2. Dong Z, Guo S, Yang Y, Wu J, Guan M, Zou H, Jin L, and Wang J. Association between ABCG2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta-analysis. Int J Rheum Dis. 2015 May;18(4):382-91. DOI:10.1111/1756-185X.12519 |
3. Wang R, Zhang J, Ma Y, Chen L, Guo S, Zhang X, Ma Y, Wu L, Pei X, Liu S, Wang J, Hu H, and Liu J. Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population. Mol Med Rep. 2014 Nov;10(5):2736-44. DOI:10.3892/mmr.2014.2536 |
4. Xiao Q, Gao S, Luo H, Fan W, Guo S, Yao H, Leng S, Xu Z, Tao T, Liu X, Jingfang Z, Zhang M, Li D, and Xiao Q. 9q33.3, a stress-related chromosome region, contributes to reducing lung squamous cell carcinoma risk. J Thorac Oncol. 2014 Jul;9(7):1041-1047. DOI:10.1097/JTO.0000000000000195 |
5. Guo S, Wang YL, Li Y, Jin L, Xiong M, Ji QH, and Wang J. Significant SNPs have limited prediction ability for thyroid cancer. Cancer Med. 2014 Jun;3(3):731-5. DOI:10.1002/cam4.211 |
6. Huang L, Li Y, Guo S, Sun Y, Zhang C, Bai Y, Li S, Yang F, Zhao M, Wang B, Yu W, Zhao M, Khor CC, and Li X. Different hereditary contribution of the CFH gene between polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese Han people. Invest Ophthalmol Vis Sci. 2014 Apr 17;55(4):2534-8. DOI:10.1167/iovs.13-13437 |
7. Song X, Guo S, Chen Y, Yang C, Ji H, Zhang F, Jiang Z, Ma Y, Li Y, Jin L, Zou H, Zhou X, and Wang J. Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to rheumatoid arthritis in Chinese Han population. J Genet. 2014 Apr;93(1):215-8. DOI:10.1007/s12041-014-0339-2 |
8. Guo S, Tan L, Pu W, Wu J, Xu K, Wu J, Li Q, Ma Y, Xu J, Jin L, and Wang J. Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer. Clin Epigenetics. 2014 Mar 24;6(1):5. DOI:10.1186/1868-7083-6-5 |
9. Wu L, Guo S, Yang D, Ma Y, Ji H, Chen Y, Zhang J, Wang Y, Jin L, Wang J, and Liu J. Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population. Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):155-60. DOI:10.1093/abbs/gmt137 |
10. Zhao Y, Xue F, Sun J, Guo S, Zhang H, Qiu B, Geng J, Gu J, Zhou X, Wang W, Zhang Z, Tang N, He Y, Yu J, and Xia Q. Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma. Clin Epigenetics. 2014;6(1):30. DOI:10.1186/1868-7083-6-30 |
11. He D, Wang J, Yi L, Guo X, Guo S, Guo G, Tu W, Wu W, Yang L, Xiao R, Li Y, Chu H, Lai S, Jin L, Zou H, Reveille JD, Assassi S, Mayes MD, and Zhou X. Association of the HLA-DRB1 with scleroderma in Chinese population. PLoS One. 2014;9(9):e106939. DOI:10.1371/journal.pone.0106939 |
12. Zhao Y, Sun J, Zhang H, Guo S, Gu J, Wang W, Tang N, Zhou X, and Yu J. High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq. Clin Epigenetics. 2014;6(1):18. DOI:10.1186/1868-7083-6-18 |
13. Wang X, Wang L, Guo S, Bao Y, Ma Y, Yan F, Xu K, Xu Z, Jin L, Lu D, Xu J, and Wang JC. Hypermethylation reduces expression of tumor-suppressor PLZF and regulates proliferation and apoptosis in non-small-cell lung cancers. FASEB J. 2013 Oct;27(10):4194-203. DOI:10.1096/fj.13-229070 |
14. Zhao Y, Zhou H, Ma K, Sun J, Feng X, Geng J, Gu J, Wang W, Zhang H, He Y, Guo S, Zhou X, Yu J, and Lin Q. Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. Oncol Lett. 2013 Apr;5(4):1211-1218. DOI:10.3892/ol.2013.1161 |
15. Lin S, Pan L, Guo S, Wu J, Jin L, Wang JC, and Wang S. Prognostic role of microRNA-181a/b in hematological malignancies: a meta-analysis. PLoS One. 2013;8(3):e59532. DOI:10.1371/journal.pone.0059532 |
16. Wu J, Wu J, Zhou Y, Zou H, Guo S, Liu J, Lu L, and Xu H. Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk. Acta Diabetol. 2012 Dec;49 Suppl 1:S87-97. DOI:10.1007/s00592-011-0336-3 |
17. Wu J, Liu J, Zhou Y, Ying J, Zou H, Guo S, Wang L, Zhao N, Hu J, Lu D, Jin L, Li Q, and Wang JC. Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. Clin Cancer Res. 2012 Jul 15;18(14):3972-81. DOI:10.1158/1078-0432.CCR-11-1531 |
18. Zhao Y, Guo S, Sun J, Huang Z, Zhu T, Zhang H, Gu J, He Y, Wang W, Ma K, Wang J, and Yu J. Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population. PLoS One. 2012;7(4):e35175. DOI:10.1371/journal.pone.0035175 |
19. He Y, Cui Y, Wang W, Gu J, Guo S, Ma K, and Luo X. Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia. 2011 Sep;13(9):841-53. DOI:10.1593/neo.11698 |
20. Li Y, Zhu J, Tian G, Li N, Li Q, Ye M, Zheng H, Yu J, Wu H, Sun J, Zhang H, Chen Q, Luo R, Chen M, He Y, Jin X, Zhang Q, Yu C, Zhou G, Sun J, Huang Y, Zheng H, Cao H, Zhou X, Guo S, Hu X, Li X, Kristiansen K, Bolund L, Xu J, Wang W, Yang H, Wang J, Li R, Beck S, Wang J, and Zhang X. The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol. 2010 Nov 9;8(11):e1000533. DOI:10.1371/journal.pbio.1000533 |
21. Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, Sun J, Zhou X, Ma K, He Y, Zhao Y, Guo S, Ye M, Guo G, Li Y, Li R, Zhang X, Ma L, Kristiansen K, Guo Q, Jiang J, Beck S, Xia Q, Wang W, and Wang J. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol. 2010 May;28(5):516-20. DOI:10.1038/nbt.1626 |

Useful links

• Dr. Kun Zhang's lab in UCSD | Dr. Kun Zhang's lab
• http://zhang.openwetware.org/ | Dr. Kun Zhang's lab
• http://be.ucsd.edu/ | Department of Bioengineering, UCSD
• https://www.uth.edu/ | The University of Texas Health Science Center at Houston
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