User:S. Saini

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Research interests

1. Network Dynamics
2. Statistics and Dynamics of Evolution in Microbial Populations
3. Bacterial Pathogenesis

Openings

• Current Openings: (1) Modeling Dynamics and Statistics of Evolution (1 position, computational) (2) Evolution of Gene Regulatory Networks (1 position, experimental & computational). Students interested in PhD positions, or Thesis Projects should write to Supreet (saini AT che.iitb.ac.in) with a copy of their CV and research interests.
• Post doctoral researchers interested in exploring a possibility of working in the lab are requested to contact Supreet with their CV and a research proposal.

Research Group

Principal Investigator

1. Supreet Saini (Assistant Professor) | PhD & MS (University of Illinois, Urbana-Champaign) | B.Tech. (IIT Delhi) | saini AT che.iitb.ac.in

Graduate Students (for PhD)

1. Manish Kumar (2010 - date) | M.Tech. (Biomineral Processing) ISM Dhanbad | manish AT iitgn.ac.in [at IIT Gandhinagar]
2. Mahendra Kumar Prajapat (2011 - date) | B.Tech. (Bioinformatics) Vellore Institute of Technology | prajapatmk.work AT gmail.com
3. Kirti Jain (2011 - date) | MSc. (Life Science) NIT Rourkela | kirtijn1 AT gmail.com
4. Debika Choudhury (2011 - date) | MSc. (Microbiology) University of Calcutta | debika217 AT gmail.com
5. Chandrani Das (2012 - date) [with Dr. Sharmila Mande, TCS]
6. Dinaker Vudhva (2014 - date) | MSc (Life Science) Jawaharlal Nehru University | dinakar.wadhwa AT gmail.com

Graduate Students (for Masters)

1. Gouri Shankar Choudhary (2012 - date)
2. Nitesh Meena (2013 - date)

Undergraduates

1. Nikhil Raj (2014 - date)
2. Piyush Lakhmani (2014 - date)
3. Amit Aggrawal (2014 - date)

Project Research Fellows

1. Divyae Prasad (2014 - date) | B.Tech (IIT Bombay)

Visiting Students

Past Members

Graduate Students (for Masters)

1. Ashish (2012 - 2014) [Co-Founder, The Zero Games Pvt. Ltd, ashish.19766 AT gmail.com]

Project Research Staff

1. Divyae Prasad (2014)

Undergraduates

1. [2013] Chaitanya Gupta, Amit Pradhan

Visiting Students

1. [2014] Sumedha Mangal (IIT BHU), Vaibhav Pathak (IIT BHU), Balaji Kumar (IIT Madras), Shriyam (Banasthali University)

Publications

1. Elementary mode analysis reveals that Clostridium acetobutylicum modulates its metabolic strategy under external stress. Molecular BioSystems (2014)
2. Acetone-butanol-ethanol fermentation analysis using only high performance liquid chromatography. Analytical Methods (2014)
3. Characterization of Performance and Dynamics of Genetic Networks. IFAC Computer Applications in Biotechnology (2013)
4. Role of feedback and network architecture in controlling virulence gene expression in Bordetella. Molecular BioSystems (2013)
5. Role of extracellular cues to trigger the metabolic phase shifting from acidogenesis to solventogenesis in Clostridium acetobutylicum. Bioresource Technology (2013)
6. Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium. Computers in Biology and Medicine (2012)
7. Continuous control of flagellar gene expression by the σ28-FlgM regulatory circuit in Salmonella enterica. Molecular Microbiology (2011)
8. The interaction dynamics of a negative feedback loop regulates flagellar number in Salmonella enterica serovar Typhimurium. Molecular Microbiology (2010)
9. FliZ induces a kinetic switch in flagellar gene expression. Journal of Bacteriology (2010)
10. Role of cross talk in regulating the dynamic expression of the flagellar Salmonella pathogenicity island 1 and type 1 fimbrial genes. Journal of Bacteriology (2010)
11. The role of coupled positive feedback in the expression of the SPI1 type three secretion system in Salmonella. PLoS Pathogens (2010)
12. SprB is the molecular link between Salmonella pathogenicity island 1 (SPI1) and SPI4. Journal of Bacteriology (2010)
13. Role of FimW, FimY, and FimZ in regulating the expression of type i fimbriae in Salmonella enterica serovar Typhimurium. Journal of Bacteriology (2009)
14. Role of feedback loops in dictating flagellar gene regulation dynamics in Salmonella typhimurium. FOSBE Proceedings IET Systems Biology (2009)
15. The rate of protein secretion dictates the temporal dynamics of flagellar gene expression. Molecular Microbiology (2008)
16. FliZ Is a posttranslational activator of FlhD4C2-dependent flagellar gene expression. Journal of Bacteriology (2008)
17. Pressure drop and heat transfer study in tube-in-tube helical heat exchanger. Chemical Engineering Science (2006)

Conference Presentations/Invited Talks

1. Revisiting Demand Rules for Gene Regulation. Center for Excellence in Basic Sciences , Mumbai (2014)
2. Characterizing Clostridium acetobutylicum metabolism using constraint-based modeling approach under stress. Clostridium XIII , China (2014)
3. Revisiting Demand Rules for Gene Regulation. FEBS-EMBO Meeting , Paris (2014)
4. Dynamic regulation of Pathogenicity Islands and Multiple Antibiotic Resistance loci in Salmonella typhimurium. FEBS-EMBO Meeting, Paris (2014)
5. Logic of Interacting Quorum Sensing Systems in Bacteria. q-Bio, Santa Fe (2014)
6. Introduction to Computational and Systems Biology. Workshop on Bioinformatics Applications and Interdisciplinary Technologies, Haffkine Institute , Mumbai (2014)
7. Counting and control in bacteria via Secretion. Bacterial Expressions, NCBS (Bangalore) (2013)
8. Impact of network map and architecture on gene expression dynamics. Foundations of Systems Biology in Engineering (FOSBE) , Tsuruoka (Japan) (2012)
9. Dynamics and Control of the Clostridium acetobutylicum metabolic network. Clostridium XII , Nottingham (United Kingdom) (2012)

Contact

1. Supreet Saini, Room 218, Assistant Professor, Chemical Engineering, IIT Bombay, Mumbai - 400 076 | Email: saini AT che.iitb.ac.in
2. BioSystems Laboratory, Department of Chemical Engineering, IIT Bombay, Mumbai - 400 076 | Phone: 91 22 2576 4286