User:RogerChang: Difference between revisions
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Roger | ==Contact Info== | ||
[[Image:OWWEmblem.png|thumb|right|Roger L. Chang (an artistic interpretation)]] | |||
*Roger L. Chang | |||
*Postdoc, lab of Pamela Silver | |||
*Systems Biology Dept, Harvard Medical School | |||
*200 Longwood Avenue WAB 561 | |||
*Boston, MA 02115 | |||
*[[Special:Emailuser/Roger L. Chang|Email me through OpenWetWare]] | |||
==Education== | |||
<!--Include info about your educational background--> | |||
* 2012, PhD in Bioinformatics and Systems Biology, University of California San Diego (lab of Bernhard Ø. Palsson) | |||
* 2005, BA in Molecular and Cell Biology, University of California Berkeley (lab of Nipam Patel) | |||
==Research interests== | |||
<!-- Feel free to add brief descriptions to your research interests as well --> | |||
# Synthetic RNA Structure Engineering | |||
# Radioresistance of Deinococcus radiodurans | |||
# Metabolic Systems Modeling | |||
# Structural Systems Biology | |||
==Publications== | |||
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | |||
<biblio> | |||
#BMC_Syst_Biol_2013_Oct_10_7-102_Antibacterial_mechanisms_identified_through_structural_systems_pharmacology pmid=24112686 | |||
#Mol_Syst_Biol_2013_Oct_1_9_693_Genome-scale_models_of_metabolism_and_gene_expression_extend_and_refine_growth_phenotype_prediction pmid=24084808 | |||
#Science_2013_Jun_7_340_1220_1223_Structural_systems_biology_evaluation_of_metabolic_thermotolerance_in_Escherichia_coli pmid=23744946 | |||
#Science_2012_Aug_31_337_1101_1104_Network_context_and_selection_in_the_evolution_to_enzyme_specificity pmid=22936779 | |||
#Mol_Syst_Biol_2011_Aug_2_7518_Metabolic_network_reconstruction_of_Chlamydomonas_offers_insight_into_light-driven_algal_metabolism pmid=21811229 | |||
#PLoS_Comput_Biol_2010_Sep_23_6_e1000938_Drug_off-target_effects_predicted_using_structural_analysis_in_the_context_of_a_metabolic_network_model pmid=20957118 | |||
#Int_J_Bioinform_Res_Appl_2010_6_101_19_Deterministic_graph-theoretic_algorithm_for_detecting_modules_in_biological_interaction_networks pmid=20223734 | |||
#Nat_Methods_2009_Aug_6_589_92_Metabolic_network_analysis_integrated_with_transcript_verification_for_sequenced_genomes pmid=19597503 | |||
#Nucleic_Acids_Res_2008_Jan_36_Database_issue_D497_503_BioHealthBase_informatics_support_in_the_elucidation_of_influenza_virus_host_pathogen_interactions_and_virulence pmid=17965094 | |||
#Bioinformatics_2007_Jan_15_23_207_214_Modular_organization_of_protein_interaction_networks pmid=17092991 | |||
</biblio> | |||
==Useful links== | |||
*[http://silver.med.harvard.edu/ Silver Lab Website] | |||
*[http://systemsbiology.ucsd.edu/ Palsson Lab Website] | |||
Revision as of 12:52, 11 March 2015
Contact Info
- Roger L. Chang
- Postdoc, lab of Pamela Silver
- Systems Biology Dept, Harvard Medical School
- 200 Longwood Avenue WAB 561
- Boston, MA 02115
- Email me through OpenWetWare
Education
- 2012, PhD in Bioinformatics and Systems Biology, University of California San Diego (lab of Bernhard Ø. Palsson)
- 2005, BA in Molecular and Cell Biology, University of California Berkeley (lab of Nipam Patel)
Research interests
- Synthetic RNA Structure Engineering
- Radioresistance of Deinococcus radiodurans
- Metabolic Systems Modeling
- Structural Systems Biology
Publications
- Chang RL, Xie L, Bourne PE, and Palsson BO. Antibacterial mechanisms identified through structural systems pharmacology. BMC Syst Biol. 2013 Oct 10;7:102. DOI:10.1186/1752-0509-7-102 |
- O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, and Palsson BØ. Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Mol Syst Biol. 2013 Oct 1;9:693. DOI:10.1038/msb.2013.52 |
- Chang RL, Andrews K, Kim D, Li Z, Godzik A, and Palsson BO. Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli. Science. 2013 Jun 7;340(6137):1220-3. DOI:10.1126/science.1234012 |
- Nam H, Lewis NE, Lerman JA, Lee DH, Chang RL, Kim D, and Palsson BO. Network context and selection in the evolution to enzyme specificity. Science. 2012 Aug 31;337(6098):1101-4. DOI:10.1126/science.1216861 |
- Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ, Salehi-Ashtiani K, and Papin JA. Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. Mol Syst Biol. 2011 Aug 2;7:518. DOI:10.1038/msb.2011.52 |
- Chang RL, Xie L, Xie L, Bourne PE, and Palsson BØ. Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput Biol. 2010 Sep 23;6(9):e1000938. DOI:10.1371/journal.pcbi.1000938 |
- Chang RL, Luo F, Johnson S, and Scheuermann RH. Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks. Int J Bioinform Res Appl. 2010;6(2):101-19. DOI:10.1504/IJBRA.2010.032115 |
- Manichaikul A, Ghamsari L, Hom EF, Lin C, Murray RR, Chang RL, Balaji S, Hao T, Shen Y, Chavali AK, Thiele I, Yang X, Fan C, Mello E, Hill DE, Vidal M, Salehi-Ashtiani K, and Papin JA. Metabolic network analysis integrated with transcript verification for sequenced genomes. Nat Methods. 2009 Aug;6(8):589-92. DOI:10.1038/nmeth.1348 |
- Squires B, Macken C, Garcia-Sastre A, Godbole S, Noronha J, Hunt V, Chang R, Larsen CN, Klem E, Biersack K, and Scheuermann RH. BioHealthBase: informatics support in the elucidation of influenza virus host pathogen interactions and virulence. Nucleic Acids Res. 2008 Jan;36(Database issue):D497-503. DOI:10.1093/nar/gkm905 |
- Luo F, Yang Y, Chen CF, Chang R, Zhou J, and Scheuermann RH. Modular organization of protein interaction networks. Bioinformatics. 2007 Jan 15;23(2):207-14. DOI:10.1093/bioinformatics/btl562 |
