User:Robert J. Tomko Jr.

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Contact Info

Robert J. Tomko Jr. (an artistic interpretation)

• Robert J. Tomko Jr.
• Yale University
• Address 1
• Address 2
• City, State, Country etc.
• Email me through OpenWetWare

I work in the Your Lab at XYZ University. I learned about OpenWetWare from Another Lab, and I've joined because Make a Lab Page.

Education

• 2008-2014, Postdoc, Molecular Biophysics and Biochemistry, Yale University
• 2008, PhD, Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine
• 2002, BS, Biochemistry and Molecular Biology, Lebanon Valley College

Research interests

1. Interest 1
2. Interest 2
3. Interest 3

Publications

1. Tomko RJ Jr and Hochstrasser M. The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis. Mol Cell. 2014 Feb 6;53(3):433-43. DOI:10.1016/j.molcel.2013.12.009 |
2. Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, and Hochstrasser M. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem. 2013 Nov 22;288(47):33682-33696. DOI:10.1074/jbc.M113.521088 |
3. Tomko RJ Jr and Hochstrasser M. Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem. 2013;82:415-45. DOI:10.1146/annurev-biochem-060410-150257 |
4. Tomko RJ Jr and Hochstrasser M. Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol Cell. 2011 Dec 23;44(6):907-17. DOI:10.1016/j.molcel.2011.11.020 |
5. Tomko RJ Jr and Hochstrasser M. Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochem Biophys. 2011 Jun;60(1-2):13-20. DOI:10.1007/s12013-011-9178-4 |
6. Heinemann IU, Randau L, Tomko RJ Jr, and Söll D. 3'-5' tRNAHis guanylyltransferase in bacteria. FEBS Lett. 2010 Aug 20;584(16):3567-72. DOI:10.1016/j.febslet.2010.07.023 |
7. Tomko RJ Jr, Funakoshi M, Schneider K, Wang J, and Hochstrasser M. Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell. 2010 May 14;38(3):393-403. DOI:10.1016/j.molcel.2010.02.035 |
8. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, and Yu J. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res. 2009 Oct 15;69(20):8157-65. DOI:10.1158/0008-5472.CAN-09-1996 |
9. Funakoshi M, Tomko RJ Jr, Kobayashi H, and Hochstrasser M. Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 2009 May 29;137(5):887-99. DOI:10.1016/j.cell.2009.04.061 |
10. Tomko RJ Jr, Azang-Njaah NN, and Lazo JS. Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition. Cell Cycle. 2009 Jan 15;8(2):299-305. DOI:10.4161/cc.8.2.7595 |
11. Tomko RJ Jr and Lazo JS. Multimodal control of Cdc25A by nitrosative stress. Cancer Res. 2008 Sep 15;68(18):7457-65. DOI:10.1158/0008-5472.CAN-08-0625 |
12. Queiroz de Oliveira PE, Tomko RJ Jr, and Lazo JS. Is a step backwards in S-phase-targeted chemotherapy a step forward?. Mol Interv. 2008 Jun;8(3):137-40. DOI:10.1124/mi.8.3.6 |
13. Brisson M, Foster C, Wipf P, Joo B, Tomko RJ Jr, Nguyen T, and Lazo JS. Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone. Mol Pharmacol. 2007 Jan;71(1):184-92. DOI:10.1124/mol.106.028589 |
14. Tomko RJ Jr, Bansal P, and Lazo JS. Airing out an antioxidant role for the tumor suppressor p53. Mol Interv. 2006 Feb;6(1):23-5, 2. DOI:10.1124/mi.6.1.5 |
15. Aponick A, Buzdygon RS, Tomko RJ Jr, Fazal AN, Shughart EL, McMaster DM, Myers MC, Pitcock WH Jr, and Wigal CT. Regioselective organocadmium alkylations of substituted quinones. J Org Chem. 2002 Jan 11;67(1):242-4. DOI:10.1021/jo016071d |

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