User:Red Group

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Red Group(an artistic interpretation)

• T/R Section Red Group
• 20.109

Possible Research Topics

1. Fusion of drugs to albumin antibodies to extend in vivo drug half-life
2. Rational design of chimeric restriction enzymes

Research Topic 1

1. Holt LJ, Basran A, Jones K, Chorlton J, Jespers LS, Brewis ND, and Tomlinson IM. Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs. Protein Eng Des Sel. 2008 May;21(5):283-8. DOI:10.1093/protein/gzm067 |

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This paper describes how fusing drugs with short half-lives to antibodies specific to albumin, which has a long half-life, extends the drug's half-life without destroying its efficacy.
Another reference is:
The pharmacokinetics of an albumin-binding Fab can be modulated as a function of affinity for albumin (Nguyen et al.) This paper describes the original creation of albumin-binding antibody-fused species, and the half-life-extending effects of this fusion.

Candidate topics for 20.109:

• Extend work to other drugs
• Test effect on IL-1ra on humans
• Explore other proteins to replace albumin, possibly increasing the effect

Research Topic 2

1. Zhang P, Bao Y, Higgins L, and Xu SY. Rational design of a chimeric endonuclease targeted to NotI recognition site. Protein Eng Des Sel. 2007 Oct;20(10):497-504. DOI:10.1093/protein/gzm049 |

   leave a comment about a paper here

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