User:Prof. Dr.: Difference between revisions
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==Research interests== | ==Research interests== | ||
<!-- Feel free to add brief descriptions to your research interests as well --> | <!-- Feel free to add brief descriptions to your research interests as well --> | ||
Lipid-Based Drug & Vaccine Delivery Systems | |||
Liposomes are one of the most versatile biochemical tools. They are microscopic, spherical closed vesicles composed of one or more lipid bilayer that form when phospholipids are hydrated. Hydrophilic molecules can be incorporated into the aqueous compartment and lipophilic molecules can be encapsulated in the lipid bilayers. Liposomes by themselves are considered nonimmunogenic, biodegradable and nontoxic. They have been utilized in numerous biomedical applications including gene therapy, for delivery of drugs and vaccines, cancer imaging agents and cosmetics. Liposomes have the capability to incorporate selected bioactive biologicals and adjuvant molecules and potentiate their efficacy and minimize their toxicity. They do this by beneficially altering the biodistribution and pharmacokinetics of the molecule in the body following its administra-tion through various routes of delivery. | |||
My research program is centered on the design, formulation, development and characterization of drug and vaccine delivery systems; particularly those based on liposomes. A special focus on the site-specific targeting controlled release, drug resistance, pharmacokinetic, pharmacodynamic, metabolism and toxicity of free and liposome-encapsulated biological active agents. | |||
Liposomal Delivery of Antisense Oligonucleotides | |||
Effect on P-glycoprotein function in multidrug resistant cells in vitro and in vivo studies. Cationic liposome formulations are used to promote the penetration of antisense oligonucleotides into the cell membrane and protect them from enzymatic degradation (nucleases). | |||
Liposomal Formulations of Drugs and Vaccines for Oral Administration | |||
Liposomes are used to protect the encapsulated agents from the harsh gastrointestinal milieu (low pH, phospholipases, and bile salts) and to enhance their absorption to the systemic circulation and to increase the efficacy of these agents while minimizing their frequency of administration. Special liposomal formulation will be prepared, characterized and assayed for their efficacy in vitro and in animal models. | |||
Liposomal Delivery of Antimicrobial Agents toward Resistant Bacteria | |||
Pulmonary and systemic infections. Construction of liposomes with high encapsulation efficiency, favorable antimicrobial release profile and enhanced bactericidal activity, to overcome the problem of bacterial resistance caused by low permeability of the bacterial cell envelope and by production of antimicrobial-inactivating enzymes. | |||
Liposomal Delivery of Antioxidants and Oxidative Stress | |||
The production of novel antioxidant carriers with increased retention profile and enhanced cellular uptake. The formulations examined in vitro protect hepatocytes from reactive oxygen species (ROS) induced injury and have increased biodistribution and pharmacokinetics in healthy rodent models. | |||
==Publications== | ==Publications== | ||
Revision as of 13:32, 20 December 2012
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Contact Info
- Prof. Dr. Abdel Omri
- Laurentian University
Director of Drug and Vaccine Delivery Systems Facility Department of Chemistry and Biochemistry Laurentian University 935 Ramsey Lake Road, Sudbury, Ontario, Canada, P3E 2C6
Education
- Year, PhD, Institute
- Year, MS, Institute
- Year, BS, Institute
Research interests
Lipid-Based Drug & Vaccine Delivery Systems Liposomes are one of the most versatile biochemical tools. They are microscopic, spherical closed vesicles composed of one or more lipid bilayer that form when phospholipids are hydrated. Hydrophilic molecules can be incorporated into the aqueous compartment and lipophilic molecules can be encapsulated in the lipid bilayers. Liposomes by themselves are considered nonimmunogenic, biodegradable and nontoxic. They have been utilized in numerous biomedical applications including gene therapy, for delivery of drugs and vaccines, cancer imaging agents and cosmetics. Liposomes have the capability to incorporate selected bioactive biologicals and adjuvant molecules and potentiate their efficacy and minimize their toxicity. They do this by beneficially altering the biodistribution and pharmacokinetics of the molecule in the body following its administra-tion through various routes of delivery.
My research program is centered on the design, formulation, development and characterization of drug and vaccine delivery systems; particularly those based on liposomes. A special focus on the site-specific targeting controlled release, drug resistance, pharmacokinetic, pharmacodynamic, metabolism and toxicity of free and liposome-encapsulated biological active agents.
Liposomal Delivery of Antisense Oligonucleotides Effect on P-glycoprotein function in multidrug resistant cells in vitro and in vivo studies. Cationic liposome formulations are used to promote the penetration of antisense oligonucleotides into the cell membrane and protect them from enzymatic degradation (nucleases).
Liposomal Formulations of Drugs and Vaccines for Oral Administration Liposomes are used to protect the encapsulated agents from the harsh gastrointestinal milieu (low pH, phospholipases, and bile salts) and to enhance their absorption to the systemic circulation and to increase the efficacy of these agents while minimizing their frequency of administration. Special liposomal formulation will be prepared, characterized and assayed for their efficacy in vitro and in animal models.
Liposomal Delivery of Antimicrobial Agents toward Resistant Bacteria Pulmonary and systemic infections. Construction of liposomes with high encapsulation efficiency, favorable antimicrobial release profile and enhanced bactericidal activity, to overcome the problem of bacterial resistance caused by low permeability of the bacterial cell envelope and by production of antimicrobial-inactivating enzymes.
Liposomal Delivery of Antioxidants and Oxidative Stress The production of novel antioxidant carriers with increased retention profile and enhanced cellular uptake. The formulations examined in vitro protect hepatocytes from reactive oxygen species (ROS) induced injury and have increased biodistribution and pharmacokinetics in healthy rodent models.
Publications
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4. DOI:10.1073/pnas.78.11.6840 |
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56. DOI:10.1016/s0022-2836(61)80072-7 |
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- ISBN:0879697164
