User:Pakpoom Subsoontorn/Notebook/general reading/2008/11/09: Difference between revisions

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==Strategic Summary: week of 11/09/08==
==Strategic Summary: week of 11/09/08==
* Genetically Encoded Memory
* Genetically Encoded Memory
** The big picture of my interests in this projects center around developing methods and managing guideline for discovering, characterizing, standardizing and presenting biological parts: enzymes, transcription factors, biochemical circuits, etc. While the size of "registered biological Parts" library of BioBrick foundation is rapidly increase, there are two important facts one needs to keep in mind. First, most of the registered parts came from specific studies from individual research groups. Synthetic biologists develop and characterize a set of parts they would like to used in the biological machines. Then, that data is put together and presented in BioBrick "standardized" format. Thus, the new Part arises in the library as a result from a specific engineering project. Second, billions years of evolutions have created huge diversity in living universe, which, of course, include the large library of naturally derived "parts"--enzymes, transcription factor, biochemical circuits, etc. Only a tiny fraction of these Parts are characterized well enough so that synthetic biology start using them to build something new. For instance, recall how many "transcription factors" and "promoters" have been identified...versus how many are frequently used by synthetic biologists to build a new living machine. I believe that it would be very useful to have a synthetic biology project that focused on large-scale characterization of these natural parts for engineering purpose. I realized that there are three major issues to be addressed
***Prioritize question and information: we don't have to know everything about a part before using for engineering
* Bacterial Cell shape
* Bacterial Cell shape


Revision as of 16:23, 9 November 2008

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Strategic Summary: week of 11/09/08

  • Genetically Encoded Memory
    • The big picture of my interests in this projects center around developing methods and managing guideline for discovering, characterizing, standardizing and presenting biological parts: enzymes, transcription factors, biochemical circuits, etc. While the size of "registered biological Parts" library of BioBrick foundation is rapidly increase, there are two important facts one needs to keep in mind. First, most of the registered parts came from specific studies from individual research groups. Synthetic biologists develop and characterize a set of parts they would like to used in the biological machines. Then, that data is put together and presented in BioBrick "standardized" format. Thus, the new Part arises in the library as a result from a specific engineering project. Second, billions years of evolutions have created huge diversity in living universe, which, of course, include the large library of naturally derived "parts"--enzymes, transcription factor, biochemical circuits, etc. Only a tiny fraction of these Parts are characterized well enough so that synthetic biology start using them to build something new. For instance, recall how many "transcription factors" and "promoters" have been identified...versus how many are frequently used by synthetic biologists to build a new living machine. I believe that it would be very useful to have a synthetic biology project that focused on large-scale characterization of these natural parts for engineering purpose. I realized that there are three major issues to be addressed
      • Prioritize question and information: we don't have to know everything about a part before using for engineering
  • Bacterial Cell shape



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