User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory

(Difference between revisions)

Revision as of 03:30, 20 October 2008

In the abstract level, how could we live with imperfect efficiency? No matter writing mechanism we choose in the end, the fraction of cells whose genome is actually rewritten will likely to be significantly less than a hundred percent.
What are the common/ different challenges between writing memory to DNA versus gene therapy/ transgenic?
Why reaction line DNA integration is irreversible but mostother don't?

reading
Next meeting: mention storyboard on interesting paper
Next meeting: mention DNA-pol in vitro selection and in vivo mutagenesis
read the poster detail from synbio 4.0, esp memory
Write up the detail structure and mechanism of integrase
discuss HT-in vivo protein evolution project with Jennifer, James, Quake's pp
Maybe I should start focusing on specific memory encoding problem..like counting the number of cell cycle.

..many signaling protein rise and fall in each cell cycle, so as the copy number of genome..we might be able to make use of them.

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 * Next meeting: mention storyboard on interesting paper
 * Next meeting: mention DNA-pol in vitro selection and in vivo mutagenesis
-* Write up the detail structure and mechanism of integrase
+* read the poster detail from synbio 4.0, esp memory
-* Take a look at how virus hijack a host and take control of host machinery (i.e. look at Covert's large
+* Write up the detail structure and mechanism of integrase
-scale viral-bacterial models). May be the first step for engineering a cell it to modify the virus to control the cell the way we want.
 * discuss HT-in vivo protein evolution project with Jennifer, James, Quake's pp
 * Maybe I should start focusing on specific memory encoding problem..like counting the number of cell cycle.