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| [[Image:KI.jpg|thumb|left|Omar F. Khan]] | | [[Image:KI.jpg|thumb|left|Omar F. Khan]] |
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| Hi, my name is [http://scholar.google.com/citations?user=XlkJ88EAAAAJ/ Omar F. Khan], and I'm currently at the [http://web.mit.edu/ Massachusetts Institute of Technology] in [http://web.mit.edu/langerlab/ Professor Robert Langer's lab] within the [http://ki.mit.edu David H. Koch Institute for Integrative Cancer Research]. I did my PhD in Chemical Engineering at the [http://www.utoronto.ca University of Toronto] under the supervision of [http://www.ibbme.utoronto.ca/faculty/core/sefton.htm Professor Michael V. Sefton]. | | Hi, my name is [http://scholar.google.com/citations?user=XlkJ88EAAAAJ Omar F. Khan], and I'm currently at the [http://web.mit.edu/ Massachusetts Institute of Technology]. I work in the labs of Professors [http://web.mit.edu/langerlab/ Robert Langer] and [http://hst.mit.edu/users/dgandermitedu Daniel G. Anderson] within the [http://ki.mit.edu David H. Koch Institute for Integrative Cancer Research]. I did my PhD in Chemical Engineering at the [http://www.utoronto.ca University of Toronto] under the supervision of [http://seftonlab.utoronto.ca/aboutsefton.html Professor Michael V. Sefton]. |
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| I work towards the treatment of damaged tissues and organs by combining nanotechnology and tissue engineering. I learned about [[OpenWetWare]] from Professor Axel Guenther and served with him on the [http://openwetware.org/wiki/TorontoMicrofluidicsFoundry Toronto Microfluidic Foundry's] Process Technology Committee. You can [[Special:Emailuser/Omar F. Khan|email me through OpenWetWare]]. | | I work towards the treatment of damaged tissues and organs by combining nanotechnology and tissue engineering. I also make universal vaccine platforms using my nanotechnology. Recently, my work was featured in the [http://ki-galleries.mit.edu/2014/khan Koch Institute Public Galleries] at MIT. To see a brief video of me describing some of my nanotechnology work, click [https://youtu.be/06mjfaP4jHY here]. |
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| == Work == | | == Work == |
| Postdoctoral Associate, Langer and Anderson Labs, Massachusetts Institute of Technology | | Postdoctoral Associate, Langer and Anderson Labs, Massachusetts Institute of Technology |
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| == Education ==
| | Please visit my main [http://web.mit.edu/ofk/www/ website] for more information: [http://web.mit.edu/ofk/www/ http://web.mit.edu/ofk/www/] |
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| Ph.D., Chemical Engineering and Applied Chemistry/Institute of Biomaterials and Biomedical Engineering, University of Toronto, 2010
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| B.A.Sc.(with honors), Chemical Engineering, University of Toronto, 2004
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| == Publications and Communications ==
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| '''Khan, O.F.,''' Zaia, E.W., Yin, H., Bogorad, R.L., Pelet, J.M., Webber, M.J., Zhuang, I., Dahlman, J.E., Langer, R. and Anderson, D.G. ''Ionizable amphiphilic dendrimer-based nanomaterials with alkyl chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.'' Angewandte Chemie International Edition, submitted Aug 13, 2014.
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| Webber, M.J, '''Khan, O.F.,''' Sydlik, S.A., Tang, B.C. and Langer, R. ''A perspective on the clinical translation of scaffolds for tissue engineering.'' Annals of Biomedical Engineering. In revision.
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| Xue, W., Dahlman, J.E., Tammela, T., '''Khan, O.F.,''' Sood, S., Dave, A., Cai, W., Chirino, L.M., Yang,G.R., Bronson, R., Crowley, D.G., Sahay,G., Schroeder, A., Langer, R., Anderson, D.G., Jacks, T. ''Small RNA combination therapy for lung cancer.'' The Proceedings of the National Academy of Sciences of the United States of America. 2014. In press.
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| '''Khan, O.F.''', Voice, D.N., Leung, B.M. and Sefton, M.V. ''A Novel High-Speed Production Process to Create Modular Components for the Bottom-Up Assembly of Large-Scale Tissue-Engineered Constructs.'' Advanced Healthcare Materials. 2014. In press.
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| Dahlman, J.E., Barnes, C., '''Khan, O.F.''', Thiriot, A., Jhunjunwala, S., Shaw, T.E., Xing, Y., Sager, H.B., Sahay, G., Speciner, L., Bader, A., Bogorad, R.L., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf,S. Dave, A., Sandu, K.S., Webber, M.J., Novobrantseva, T., Ruda, V.M., Lytton-Jean, A.K.R., Levins, C.G., Kalish, B., Mudge, D.K., Perez, M., Abezgauz, L., Dutta, P., Smith, S., Charisse, K., Kieran, M.W., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R.M., von Andrian, U.H., Akinc, A., Schroeder, A., Panigrahy, D., Koteliansky, V., Langer, R.S., and Anderson, D.G. ''Low molecular weight polymeric materials for nanoparticle-mediated in vivo endothelial siRNA delivery.'' Nature Nanotechnology. 2014. In press.
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| Dong, Y., Eltoukhy, A.A., Alabi, C.A., '''Khan, O.F.''', Veiseh, O., Dorkin, J.R., Sirirungruang, S., Yin, H., Tang, B.C., Pelet, J.M., Chen, D., Zhen, G., Xue, Y., Langer, R.S. and Anderson, D.G. ''Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.'' Advanced Healthcare Materials. 2014. In press.
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| '''Khan, O.F.''', Chamberlain, M.D. and Sefton, M.V. ''Toward an in vitro vasculature: differentiation of mesenchymal stromal cells within an endothelial cell-seeded modular construct in a microfluidic flow chamber.'' Tissue Engineering Part A. 2012 Apr;18(7-8):744-56
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| '''Khan, O.F.''' and Sefton, M.V. ''Endothelialized biomaterials for tissue engineering applications in vivo.'' Trends in Biotechnology, 2011 Aug;29(8):379-87.
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| '''Khan, O.F.''' and Sefton, M.V. ''Patterning collagen/poloxamine-methacrylate hydrogels for tissue engineering-inspired microfluidic and laser lithography applications.'' Journal of Biomaterials Science: Polymer Edition. 2011 Jan;22(18): 2499-2514
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| Chamberlain, M.D., Butler, M.J., Ciucurel, E.C., Fitzpatrick, L.E., '''Khan, O.F.''', Leung, B.M., Lo, C., Patel, R., Velchinskaya, A., Voice, D.N. and Sefton, M.V. ''Fabrication of Micro-Tissues using Modules of Collagen Gel Containing Cells.'' Journal of Visualized Experiments, DOI: 10.3791/2177
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| '''Khan, O.F.''' and Sefton, M.V. ''Endothelial Cell Behaviour within a Microfluidic Mimic of the Flow Channels of a Modular Tissue Engineered Construct.'' Biomedical Microdevices, 2011 Feb;13(1):69-87.
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| '''Khan, O.F.''' and Sefton, M.V. ''Perfusion and Characterization of an Endothelial Cell-Seeded Modular Tissue Engineered Construct Formed in a Microfluidic Remodeling Chamber.'' Biomaterials, 2010 Nov;31(32):8254-61
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| '''Khan, O.F.''', Jean-Francois, J. and Sefton, M.V. ''MMP Levels in the Response to Degradable Implants in the Presence of a Hydroxamate-Based Matrix Metalloproteinase Sequestering Biomaterial In Vivo.'' Journal of Biomedical Materials Research, Part A, 2010 Jun 15;93(4):1368-79.
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| Sosnik A., '''Khan O.F.''', Butler M, Sefton M.V.: ''Poloxamine hydrogels: From non-cell adhesive substrates to matrices with improved cytocompatibility for Tissue Engineering applications.'' In Barbucci, R. (Ed.), Hydrogels: Biological Properties and Applications. Springer; 2009.
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| == Conferences ==
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| '''Khan, O.F.''', Chamberlain, M.D., Dahlman, J.E., Sefton, M.V., Langer, R.S. and Anderson, D.G. "Modular Tissue Containing Endothelial and Mesenchymal Stem Cells formed in a Microfluidic Perfusion Chamber." The 11th US-Japan Symposium on Drug Delivery Systems Conference, Lahaina, Maui, USA, December 16-20, 2011. Poster Presentation
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| Voice, D.N., '''Khan, O.F.''', Leung, B.M. and Sefton, M.V. “High throughput module production and applications to cardiac tissue engineering.” Ontario-on-a-Chip, Toronto, Ontario, Canada, June 9-10, 2011. Poster Presentation
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| Voice, D.N., '''Khan, O.F.''', Leung, B.M. and Sefton, M.V. “A novel plug flow process for high throughput modular tissue engineering.” Canadian Biomaterials Society, 29th Annual Conference, Vancouver, British Columbia, Canada, June 1-4, 2011. Oral presentation
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| '''Khan, O.F.''', Chamberlain, M.D. and Sefton, M.V. “Modular Tissue Containing Endothelial Cells and Mesenchymal Stem Cells formed in a Microfluidic Perfusion Chamber.” Tissue Engineering and Regenerative Medicine International Society (TERMIS)-European Union Chapter Meeting, Galway, Ireland, June 13-17, 2010. Oral Presentation
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| '''Khan, O.F.''', Leung, B.M. and Sefton, M.V. “Modular Cardiac Tissue Containing Endothelial and Cardiomyocyte Cells formed in a Microfluidic Perfusion Chamber,” Ontario-on-a-Chip, Toronto, ON., Canada, May 20-21, 2010. Oral Presentation
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| '''Khan, O.F.''' and Sefton, M.V. “Collagen/Poloxamine Microfluidic Flow Circuits to Characterize Surface-Attached Endothelial Cells Under Flow.” 8th World Biomaterials Congress, Amsterdam, The Netherlands, May 28-June 1, 2008. Oral Presentation
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| '''Khan, O.F.''' and Sefton, M.V. “In Vivo Use of a Matrix Metalloproteinase-Sequestering Biomaterial to Alter the Inflammatory Response,” Regenerate World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, Pennsylvania, USA, April 23-27, 2006. Poster Presentation
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| '''Khan, O.F.''' and Sefton, M.V. “In Vivo Alteration of the Foreign Body Response Using a Matrix Metalloproteinase-Sequestering Biomaterial,” Challenges in Regenerative Medicine (ChaRM), Toronto, Ontario, Canada, October 20-21, 2005. Poster Presentation
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| == Patents and Inventions ==
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| '''Khan, O.F.''', Zaia, E.W., Langer, R.S. and Anderson, D.G. Modified poly(ether sulfone) materials with improved angiogenic responses in vivo. MIT case ID 16924
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| '''Khan, O.F.''', Langer, R.S. and Anderson, D.G. Methodology for producing insulin-secreting devices using a modular approach. MIT case ID 16925
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| '''Khan, O.F.''', Dahlman, J.D., Dong, Y., Anderson, D.G. and Langer, R.S. Degradable and non-degradable dendrimer-based lipidoids and uses thereof. MIT case ID 16054
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