User:Megan N McClean: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
 
(22 intermediate revisions by 3 users not shown)
Line 1: Line 1:
<!-- Delete this entire line as part of your first edit of your user page --> {{New user}}
<div style="padding: 10px; color: #000000; background-color: #DCDCDC">


==Contact Info==
==Contact Info==
[[Image:Horseshoe.jpg|thumb|right|Megan N McClean (an artistic interpretation)]]
[[Image:Megan1.jpg|150px|right|Megan N. McClean]]


*Megan N McClean
*Megan N McClean
<!--
Cameron changed this on 6/2/2015
*Princeton University
*Princeton University
*120 Carl Icahn Laboratory
*120 Carl Icahn Laboratory
*Princeton, NJ 08544 USA  
*Princeton, NJ 08544 USA -->
*University of Wisconsin
*Engineering Centers Building 3156
*1550 Engineering Drive
*Madison, WI 53706
*[[Special:Emailuser/Megan N McClean|Email me through OpenWetWare]]
*[[Special:Emailuser/Megan N McClean|Email me through OpenWetWare]]


I am a Lewis-Sigler fellow at Princeton.


 
<!--I am a Lewis-Sigler fellow at Princeton University.-->
 
I am an assistant professor at the University of Wisconsin.
 
<a href="http://www.labmeeting.com/public/profile/82800/megan-nicole-mcclean"><img style="border:0" src="http://embed.labmeeting.com/images/badges/viewmyprofile102x33.gif" title="Megan Nicole McClean on Labmeeting" alt="Megan Nicole McClean on Labmeeting" /></a>


==Education==
==Education==
<!--Include info about your educational background-->
<!--Include info about your educational background-->
* 2009-2014, Lewis-Sigler Fellow, Princeton University<!-- Added by Cameron 6/2/2015-->
* 2009, PhD, Harvard
* 2009, PhD, Harvard
* 2005, MS, Harvard
* 2005, MS, Harvard
Line 25: Line 29:
==Research interests==
==Research interests==
<!-- Feel free to add brief descriptions to your research interests as well -->
<!-- Feel free to add brief descriptions to your research interests as well -->
# Cellular decision-making processes
The McClean lab studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell, where successive cellular responses take place. How these networks process their input dictates cellular behavior and fitness. We are interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. We are also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). The lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.
# In vivo kinetics of signaling cascades
 
Please check out my Princeton webpage here: [http://www.princeton.edu/genomics/mcclean/ McClean Lab at Princeton ]
 
Check out our lab webpage on openwetware here: [http://openwetware.org/wiki/McClean McClean Lab on Openwetware]


==Publications==
==Publications==
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<biblio>
<biblio>
#Paper pmid=18480263
#Paper1 pmid=18480263
 
#Paper2 pmid=17259986
#Paper pmid=17259986
#Paper3 pmid=19177008  
 
#Paper4 pmid=19116106
#Paper pmid=19177008  
#Paper pmid=19116106
</biblio>
</biblio>
==Useful links==
==Useful links==
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[Help|OpenWetWare help pages]]
*[[Help|OpenWetWare help pages]]

Latest revision as of 13:56, 2 June 2015

Contact Info

Megan N. McClean
Megan N. McClean
  • Megan N McClean
  • University of Wisconsin
  • Engineering Centers Building 3156
  • 1550 Engineering Drive
  • Madison, WI 53706
  • Email me through OpenWetWare


I am an assistant professor at the University of Wisconsin.

Education

  • 2009-2014, Lewis-Sigler Fellow, Princeton University
  • 2009, PhD, Harvard
  • 2005, MS, Harvard
  • 2003, BA, University of California at Berkeley

Research interests

The McClean lab studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell, where successive cellular responses take place. How these networks process their input dictates cellular behavior and fitness. We are interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. We are also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). The lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.

Please check out my Princeton webpage here: McClean Lab at Princeton

Check out our lab webpage on openwetware here: McClean Lab on Openwetware

Publications

  1. Hersen P, McClean MN, Mahadevan L, and Ramanathan S. Signal processing by the HOG MAP kinase pathway. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7165-70. DOI:10.1073/pnas.0710770105 | PubMed ID:18480263 | HubMed [Paper1]
  2. McClean MN, Mody A, Broach JR, and Ramanathan S. Cross-talk and decision making in MAP kinase pathways. Nat Genet. 2007 Mar;39(3):409-14. DOI:10.1038/ng1957 | PubMed ID:17259986 | HubMed [Paper2]
  3. McClean MN, Hersen P, and Ramanathan S. In vivo measurement of signaling cascade dynamics. Cell Cycle. 2009 Feb 1;8(3):373-6. DOI:10.4161/cc.8.3.7450 | PubMed ID:19177008 | HubMed [Paper3]
  4. Hersen P, McClean M, and Ramanathan S. [Dynamic analysis of cell signalling: the example of the Saccharomyces cerevisiae osmotic response]. Med Sci (Paris). 2008 Dec;24(12):1020-2. DOI:10.1051/medsci/200824121020 | PubMed ID:19116106 | HubMed [Paper4]
All Medline abstracts: PubMed | HubMed

Useful links