User:Maureen McKeague

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[[Image:OWWEmblem.png|thumb|right|Maureen McKeague (an artistic interpretation)]]
[[Image:OWWEmblem.png|thumb|right|Maureen McKeague (an artistic interpretation)]]
<br>'''Maureen McKeague'''
<br>'''Maureen McKeague'''
-
<br>[http://www.stanford.edu/ Stanford University][http://openwetware.org/wiki/Smolke_Lab/Smolke Laboratory]
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<br>[http://www.stanford.edu/ Stanford University],http://openwetware.org/wiki/Smolke_Lab/ Smolke Laboratory]
<br>1125 Colonel By Drive
<br>1125 Colonel By Drive
<br>Ottawa, ON, Canada
<br>Ottawa, ON, Canada

Revision as of 18:34, 2 September 2012

Contents

Contact Info

Maureen McKeague (an artistic interpretation)
Maureen McKeague (an artistic interpretation)


Maureen McKeague
Stanford University,http://openwetware.org/wiki/Smolke_Lab/ Smolke Laboratory]
1125 Colonel By Drive
Ottawa, ON, Canada
Email me through OpenWetWare

I work in the DeRosa lab at Carleton University.

Education

Research interests

My PhD research involves improving the Systematic Evolution of Ligands by Exponential enrichment (SELEX) process using a combination of experimental and computational methods. I am also applying the improved SELEX technique to produce aptamers that can recognize and bind to mycotoxins (fungal metabolites) with high affinity. It is estimated that at least 25% of the grain produced worldwide is contaminated with mycotoxins. In Canada, three mycotoxins of major concern include fumonisin B1 (FB1), deoxynivalenol (DON) and ochratoxin A (OA). Mycotoxin exposure leads to a variety of pathologies including vomiting (DON); kidney disease (OA, FB1); neurological disorders (FB1); disease of the lung and liver (FB1); cancer (OA, FB1) and death (FB1, OA). While traditional food safety testing techniques to detect mycotoxins exist; there is a need for more rapid and cost-effective approaches. We expect that the relatively new technology of aptamers is a viable alternative for use in food testing, specifically for mycotoxin detection.

Publications

  1. Cruz-Toledo, J.; McKeague, M.; Zhang, X.; Giamberardino, A.; McConnell, E.; Francis, T.; DeRosa, M.C.; Dumontier, M. Aptamer Base: A collaborative knowledge base to describe aptamers and SELEX experiments. Database: Journal of Biological Databases and Curation. 2012.
  2. McKeague, M.; Giamberardino, A.; DeRosa, M.C. Advances in Aptamer-Based Biosensors for Food Safety, Environmental Biosensors. 2011, Vernon Somerset (Ed.) ISBN: 9789533074863, InTech.
  3. De Girolamo, A.; McKeague, M.; Miller, J.D.; DeRosa, M.C.; Visconti, A. Determination of Ochratoxin A in Wheat After Clean-Up through a DNA Aptamer-Based Solid Phase Extraction Column. Food Chem. 2011, 127, 1378-1384.
  4. McKeague, M.; Bradley, C.R.; De Girolamo, A.; Visconti, A.; Miller, J.D.; Derosa, M.C. Screening and Initial Binding Assessment of Fumonisin B(1) Aptamers. Int. J. Mol. Sci. 2010, 11, 4864-4881.
  5. Luo, X.; McKeague, M.; Pitre, S.; Dumontier, M.; Green, J.; Golshani, A.; Derosa, M.C.; Dehne, F. Computational Approaches Toward the Design of Pools for the in Vitro Selection of Complex Aptamers. RNA. 2010, 16, 2252-2262.

Useful links

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