User:Maureen McKeague: Difference between revisions
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==Publications== | ==Publications== | ||
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | <!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications. You can add or remove lines as needed --> | ||
#Valenzano, S.; De Girolamo, A.; DeRosa, M.C.; McKeague, M.; Schena, R.; Catucci, L.; Pascale, M. [http://pubs.acs.org/doi/pdf/10.1021/acscombsci.5b00163 Screening and Identification of DNA Aptamers to Tyramine Using in Vitro Selection and High-Throughput Sequencing]. ACS Comb Sci. 2016. | #Valenzano, S.; De Girolamo, A.; DeRosa, M.C.; McKeague, M.; Schena, R.; Catucci, L.; Pascale, M. [http://pubs.acs.org/doi/pdf/10.1021/acscombsci.5b00163 Screening and Identification of DNA Aptamers to Tyramine Using in Vitro Selection and High-Throughput Sequencing]. ACS Comb Sci. 2016, 18 (6), 302–313. | ||
#McKeague, M.; Wong, R.S.; Smolke, C.D. [http://nar.oxfordjournals.org/content/early/2016/03/10/nar.gkw151.abstract?keytype=ref&ijkey=P6DDJUKcmpn8XIM Opportunities in the design and application of RNA for gene expression control] NAR, 2016 | #McKeague, M.; Wong, R.S.; Smolke, C.D. [http://nar.oxfordjournals.org/content/early/2016/03/10/nar.gkw151.abstract?keytype=ref&ijkey=P6DDJUKcmpn8XIM Opportunities in the design and application of RNA for gene expression control] NAR, 2016, 44 (7),2987-2999 | ||
#McKeague, M.; Wang, Y-H.; Smolke, C.D. [http://pubs.acs.org/doi/abs/10.1021/acschembio.5b00518 In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control] ACS Chem. Biol, 2015, 10 (11), 2463–2467. | #McKeague, M.; Wang, Y-H.; Smolke, C.D. [http://pubs.acs.org/doi/abs/10.1021/acschembio.5b00518 In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control] ACS Chem. Biol, 2015, 10 (11), 2463–2467. | ||
#McKeague, M.; McConnell, E.M.; Cruz-Toledo, J.; Bernard, E.D.; Pach, A.; Zhang, X.; Beking, M.; Francis, T.; Giamberardino, A.; Cabecinha, A.; Ruscito, A.; Aranda-Rodriguez, R.; Dumontier, M.; DeRosa, M.C. [http://link.springer.com/article/10.1007%2Fs00239-015-9708-6 Analysis of In Vitro Aptamer Selection Parameters]. J Mol Evol. 2015, 81(5), 150-161. | #McKeague, M.; McConnell, E.M.; Cruz-Toledo, J.; Bernard, E.D.; Pach, A.; Zhang, X.; Beking, M.; Francis, T.; Giamberardino, A.; Cabecinha, A.; Ruscito, A.; Aranda-Rodriguez, R.; Dumontier, M.; DeRosa, M.C. [http://link.springer.com/article/10.1007%2Fs00239-015-9708-6 Analysis of In Vitro Aptamer Selection Parameters]. J Mol Evol. 2015, 81(5), 150-161. |
Revision as of 12:11, 16 June 2016
Contact Info
Maureen McKeague
Stanford University
Shriram Center, Room 256
Mail Code 4245
443 Via Ortega
Stanford, CA 94305
Email me through OpenWetWare
I work in the Smolke lab
Education
- 2007-2012: PhD in Chemistry,Carleton University in the DeRosa lab
- 2003-2007: BSc in Biochemistry and Biotechnology, Carleton University
Research interests
I am passionate about improving human health and quality of life using functional nucleic acids. Specifically, my past, current & future research aims to improve the selection and characterization of small molecule-binding aptamers and ribozymes towards the ultimate goal of developing both in vitro and in vivo biosensors for high-throughput drug screening and disease diagnosis.
Publications
- Valenzano, S.; De Girolamo, A.; DeRosa, M.C.; McKeague, M.; Schena, R.; Catucci, L.; Pascale, M. Screening and Identification of DNA Aptamers to Tyramine Using in Vitro Selection and High-Throughput Sequencing. ACS Comb Sci. 2016, 18 (6), 302–313.
- McKeague, M.; Wong, R.S.; Smolke, C.D. Opportunities in the design and application of RNA for gene expression control NAR, 2016, 44 (7),2987-2999
- McKeague, M.; Wang, Y-H.; Smolke, C.D. In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control ACS Chem. Biol, 2015, 10 (11), 2463–2467.
- McKeague, M.; McConnell, E.M.; Cruz-Toledo, J.; Bernard, E.D.; Pach, A.; Zhang, X.; Beking, M.; Francis, T.; Giamberardino, A.; Cabecinha, A.; Ruscito, A.; Aranda-Rodriguez, R.; Dumontier, M.; DeRosa, M.C. Analysis of In Vitro Aptamer Selection Parameters. J Mol Evol. 2015, 81(5), 150-161.
- Frost, N.R.; McKeague, M.; Falcioni, D.; DeRosa, M.C. An in Solution Assay For Parallel Interrogation of Structure and Affinity of Small Molecule-Binding Aptamers, Analyst 2015, 140 (8) 6643–6651.
- McKeague, M.; De Girolamo, A.; Valenzano, S.; Pascale, M.; Ruscito, A.; Ranganathan, V.; Frost, N.; Hill, K.; Smith, M.; McConnell, E.; DeRosa, M.C.Comprehensive Analytical Comparison of Strategies Used for Small Molecule Aptamer Evaluation, Analytical Chemistry, 2015, 87 (17), 8608–8612.
- Chang, A.L.; McKeague, M.; Smolke, C.D. Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance In: Burke-Aguero, D., editor. Methods in Enzymology. 2014, 549, 451-466.
- McKeague, M.; DeRosa, M.C. Aptamers and SELEX: Tools for the Development of Transformative Molecular Recognition Technology, Aptamers and Synthetic Antibodies, 2014, 1 (1), 12-16.
- McKeague, M.; Ranganathan, V.; Hill, K.; Bardozy, V.; Mezaros, T.; DeRosa, M.C. Selection and Characterization of a Novel DNA Aptamer For Label-Free Fluorescence Biosensing of Ochratoxin A, Toxins, 2014, 6 (8), 2435-2452.
- Chang A.L.; McKeague, M.; Liang, J.C.; Smolke, C.D. Kinetic and Equilibrium Binding Characterization of Aptamers to Small Molecules using a Label-Free, Sensitive, and Scalable Platform, Analytical Chemistry, 2014, 86 (7), 3273–3278.
- Mastronardi, E.; McKeague, M.; Monreal, C.; DeRosa, M.C. Development and Application of Crop Exudate Specific Aptamers, Journal of Biomolecular Structure and Dynamics, 2013, 31 (1), 89.
- McKeague, M.; Foster, A.; Miguel, Y.; Giamberardino, A.; Verdin, C.; Chan, J.Y.; DeRosa, M.C. Development of a DNA aptamer for direct and selective homocysteine detection in human serum, RSC Advances, 2013, 3 (46), 24415-24422.
- McKeague, M.; DeRosa, M.C. Challenges and Opportunities for Small Molecule Aptamer Development, Journal of Nucleic Acids, 2012.
- Cruz-Toledo, J.; McKeague, M.; Zhang, X.; Giamberardino, A.; McConnell, E.; Francis, T.; DeRosa, M.C.; Dumontier, M. Aptamer Base: A collaborative knowledge base to describe aptamers and SELEX experiments. Database: Journal of Biological Databases and Curation. 2012.
- McKeague, M.; Giamberardino, A.; DeRosa, M.C. Advances in Aptamer-Based Biosensors for Food Safety, Environmental Biosensors. 2011, Vernon Somerset (Ed.) ISBN: 9789533074863, InTech. DOI:10.5772/22350
- De Girolamo, A.; McKeague, M.; Miller, J.D.; DeRosa, M.C.; Visconti, A. Determination of Ochratoxin A in Wheat After Clean-Up through a DNA Aptamer-Based Solid Phase Extraction Column. Food Chem. 2011, 127 (3), 1378-1384.
- McKeague, M.; Bradley, C.R.; De Girolamo, A.; Visconti, A.; Miller, J.D.; Derosa, M.C. Screening and Initial Binding Assessment of Fumonisin B(1) Aptamers, Int. J. Mol. Sci. 2010, 11 (12), 4864-4881.
- Luo, X.; McKeague, M.; Pitre, S.; Dumontier, M.; Green, J.; Golshani, A.; Derosa, M.C.; Dehne, F. Computational Approaches Toward the Design of Pools for the in Vitro Selection of Complex Aptamers, RNA. 2010, 16 (11), 2252-2262.
Useful links
- Dance Your PhD 2010 SELEX Dance
- My LinkedIn profile
- Full curriculum vitae
- Interview with the Oligonucleotide Therapeutics Society
- International Society on Aptamers
- Building a search engine for aptamers! Aptamer Base
- 2015 Analytical Chemistry LiveSlides