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[[Image:MarkBlenner.png|thumb|right|Mark Blenner]] | [[Image:MarkBlenner.png|thumb|right|Mark Blenner]] | ||
Currently, I am a Research Fellow in the [http://labs.idi.harvard.edu/springer/ | Currently, I am a Research Fellow in the [http://labs.idi.harvard.edu/springer/ Springer Lab] at the [http://www.idi.harvard.edu/ Immune Disease Institute] affiliated with Harvard Medical School and Children's Hospital Boston. <br/> | ||
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Revision as of 09:05, 14 November 2011
Mark Blenner
Currently, I am a Research Fellow in the Springer Lab at the Immune Disease Institute affiliated with Harvard Medical School and Children's Hospital Boston.
Previously, I worked in the Banta Lab of Protein and Metabolic Engineering at Columbia University.
Mailing Address:
3 Blackfan Circle
CLSB - 3rd Floor - Springer Lab
Boston, MA 02115
blenner@idi.harvard.edu
Education
- Current, Postdoctoral Fellow, Harvard Medical School (Immune Disease Institute)
- 2009, PhD, Columbia University (Chemical Engineering)
- 2007, MS, Columbia University (Chemical Engineering)
- 2004, BS, Manhattan College (Chemical Engineering) Summa Cum Laude
Research interests
My research interests involve studying and engineering protein conformational change. Using a combination of biochemical, biophysical and single-molecule techniques, we can begin to understand the complex ways in which proteins are able to regulate their properties. Using protein engineering tools, such as directed evolution and other high throughput technologies, we can better understand protein conformational changes and create proteins with useful properties not found in nature. This work sheds new light on biological function and pathological dysfunction. This knowledge is used to design advanced biotechnologies addressing problems in bioenergy, sustainability, and human health.
My future research interests focus on the design of in vivo protein biosensors in metabolic engineering for pathway optimization, pathways discovery, and enzyme engineering. My background in protein engineering and structural biology will enable novel approaches to problems in the field of metabolic engineering.
- Protein Engineering
- Metabolic Engineering
- Synthetic Biology
- Biological Conformational Switches
- Directed Evolution & High Throughput Technologies
- Single-molecule Biophysics
- Structural Biology
Awards & Honors
- Ruth Kirschstein F32 National Research Service Award Postdoctoral Fellowship (2011-Current)
- American Heart Association Postdoctoral Fellowship (2010)
- Draddy Medal for Excellence in Engineering (2004)
Professional Service
- Cochair for "Advances in Protein Folding and Post-translational Modifications" AIChE 2012
Publications
- Banta, S., Wheeldon, I., Blenner, M. (2010) “Protein engineering in the development of functional hydrogels” Annual Reviews in Biomedical Engineering, 12 167-186.
- Blenner, M., Shur, O., Szilvay, G., Cropeck, D., Banta, S. (2010), “Calcium induced folding of a Repeat in Toxin (RTX)- Domain Via C-Terminal Entropic Stabilization” Journal of Molecular Biology. 400(2) 244-256.
- Szilvay, G., Blenner, M., Cropeck, D., Banta, S. (2009) “A FRET-based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase” Biochemistry 48(47) 11273-11282.
- Blenner, M., Banta, S. (2008) “Characterization of the 4D5Flu single chain antibody with a stimulus-responsive elastin-like peptide linker: A potential reporter of peptide linker conformation” Protein Science 17(3) 527-536.
- Chockalingam, K., Blenner, M., Banta, S. (2007) “Design and application of stimulus responsive peptide systems” Protein Engineering Design and Selection 20(4) 155-61.
