User:Kevin Dooley

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==Research interests==
==Research interests==
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# Engineering molecular recognition
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# The majority of my research focuses on engineering a conformationally dynamic peptide isolated from a repeats-in-toxin (RTX) domain.  This protein scaffold undergoes a reversible structural rearrangement in response to low millimolar concentrations of calcium from an intrinsically disordered state to a compact β-roll structure. 
# Engineering stimulus responsive biomaterials
# Engineering stimulus responsive biomaterials
# Engineering novel cell penetrating peptides for targeted drug delivery
# Engineering novel cell penetrating peptides for targeted drug delivery

Revision as of 11:28, 5 August 2014


Contents

Contact Info

Kevin Dooley
Kevin Dooley
  • Kevin Dooley
  • Columbia University
  • 500 W120th Street
  • Mudd 801
  • New York, NY 10027
  • kpd2109@columbia.edu

I work in Scott Banta's Protein and Metabolic Engineering Lab at Columbia University.

Education

  • 2014 (expected), PhD, Chemical Engineering, Columbia University, New York, NY
  • 2009, MS, Chemical Engineering, Manhattan College, Bronx, NY
  • 2008, BS, Chemical Engineering, Manhattan College, Bronx, NY

Research interests

  1. The majority of my research focuses on engineering a conformationally dynamic peptide isolated from a repeats-in-toxin (RTX) domain. This protein scaffold undergoes a reversible structural rearrangement in response to low millimolar concentrations of calcium from an intrinsically disordered state to a compact β-roll structure.
  2. Engineering stimulus responsive biomaterials
  3. Engineering novel cell penetrating peptides for targeted drug delivery

Publications

  1. Banta, S Dooley, K, Shur, O. 2013. Replacing antibodies: Engineering new binding proteins. Annual review of biomedical engineering 15: 93-113
  2. Shur O, Dooley K, Blenner M, Baltimore M, Banta S. 2013. A designed, phase-changing RTX-based peptide for efficient bioseparations. Biotechniques 54(4): 197-206
  3. Dooley K, Kim YH, Lu HD, Tu R, Banta S. 2012. Engineering of an Environmentally Responsive Beta Roll Peptide for Use As a Calcium-Dependent Cross-Linking Domain for Peptide Hydrogel Formation. Biomacromolecules 13: 1758-64
  4. Wu J, Park JP, Dooley K, Cropek DM, West AC, Banta S. 2011. Rapid Development of New Protein Biosensors Utilizing Peptides Obtained via Phage Display. PLOS ONE 6: e24948
  5. Sahin A, Dooley K, Cropek DM, West AC, Banta S. 2011. A dual enzyme electrochemical assay for the detection of organophosphorus compounds using organophosphorus hydrolase and horseradish peroxidase. Sensors and Actuators B: Chemical 158: 353-60
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