User:Jungwhan Kim

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Revision as of 18:19, 28 February 2012

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Contents

JHIBRG Member


Jungwhan Kim, D.V.M., Ph.D.

Post-Doctoral Fellow (Randall Johnson Lab)

Division of Biological Sciences

University of California, San Diego (UCSD)

9500 Gilman Drive NSB 5325A, La Jolla, CA 92093

Lab Tel) 858-822-5832

Email: vetjayk@gmail.com


Current Research Interests

  1. The role of stromal hypoxic responses in the development of breast cancer
  2. The role of hypoxia-inducible factors (HIFs) in adipogenesis


Previous Research Interests

  1. Cancer Metabolism; Oncogenic and hypoxic alterations of cellular metabolism by c-Myc and HIF-1.
  2. Metabolic reprogramming of cells by hypoxic induction of pyruvate dehydrogenase kinase 1 (PDK1).


Education and Professional Training


Academic Awards

  • Achievement Award for the 1st rank in The Veterinary National Board Examination, Korea (2000)
  • Dean’s Award for Academic Achievement, summa cum laude, Kon-kuk University, School of Veterinary Medicine, Seoul, Korea (2000)
  • Howard Hughes Medical Institute (HHMI), Pre-Doctoral Fellowship (2003 - 2006)
  • Pathology Young Investigators’ day Award, Excellence in Basic Research, Dept. of Pathology, Johns Hopkins, School of Medicine (2004)
  • Keystone Symposia Scholarship, Metabolomics: From Bioenergetics to Apoptosis (2006)
  • Susan G. Komen Foundation Post-Doctoral Fellowship (2008)
  • NIH T32 Postdoctoral Fellowship (2010-2011)
  • NIH F32 Postdoctoral Fellowship (2011-2013)
  • Keystone Symposia Scholarship, Advances in Hypoxia (2012)


Publications (Link to Full Text)

Nature Reviews Cancer Cover Jan 2008
Nature Reviews Cancer Cover Jan 2008
Cell Metabolism Cover Mar 2006
Cell Metabolism Cover Mar 2006
  1. Norihiko Takeda, Ellen L. O’Dea, Andrew Doedens, Jung-whan Kim, Alexander Weidmann, Christian Stockmann, Masataka Asagiri, M. Selete Simon, Alexander Hoffmann and Randall S. Johnson. Differential activation and antagonistic function of HIF-a isoforms in macrophages are essential for NO homeostasis. Genes Dev. 24:491-501 (2010)
  2. Jung-whan Kim and Randall S. Johnson. You Don't need a PHD to Grow a Tumor. Developmental Cell 16:781-2 (2009)
  3. Hosein Kouros-Mehr, Jung-whan Kim, Seth K. Bechis, and Zena Werb. GATA-3 and the Regulation of the Mammary Luminal Cell Fate. Current Opinion in Cell Biology 20:164-170 (2008)
  4. Chi V. Dang, Jung-whan Kim, Ping Gao, and Jason Yustein. The Interplay between MYC and HIF in Cancer. Nature Reviews Cancer 8:51-56 (2008)
  5. Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza and Chi V. Dang. HIF-1 and dysregulated c-Myc cooperatively induce VEGF and metabolic switches, HK2 and PDK1. Mol. Cell. Biol. 27:7381-7393 (2007)
  6. Jung-whan Kim, Ping Gao, and Chi V. Dnag. Effects of hypoxia on tumor metabolism. Cancer and Metastasis Reviews. 26:291-8 (2007)
  7. Ryo Fukuda, Huafeng Zhang, Jung-whan Kim, Larissa Shimoda, Chi V. Dang, and Gregg L. Semenza. HIF-1 regulates cytochrome oxidase subunit composition to optimize the efficiency of respiration of hypoxic cells. Cell 129:111-122 (2007)
  8. Jung-whan Kim, and Chi V. Dang. Cancer's molecular sweet tooth and the Warburg effect. Cancer Research 66:8927-8930 (2006)
  9. Jung-whan Kim, Irina Tchernyshyov, Gregg L. Semenza, and Chi V. Dang. HIF-1-mediated expression of PDK: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3:177-185 (2006)
  10. Kathryn O'Donnell, Duonan Yu, Karen I. Zeller, Jung-whan Kim, Frederick Racke, Andrei Thomas-Tikhonenko and Chi V. Dang. Transferrin Receptor 1 is a direct Myc target gene required for cell cycle progression, Mol. Cell. Biol. 26:2373-2386 (2006)
  11. Rong Mao, Xiaowen Wang, Edward L. Spitznagel Jr., Laurence P. Frelin, Jason C. Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J. Downey, and Jonathan Pevsner. Role of Gene Expression in the Developing Human Down Syndrome Brain and Heart. Genome Biology, 6:R107 (2005)
  12. Jung-whan Kim, Lawrence B. Gardner and Chi V. Dang. Oncogenic Alterations of Metabolism and the Warburg Effect. Drug Discovery Today: Disease Mechanisms, 2:233-235 (2005)
  13. Feng Li, Diane Wonsey, Young Ko, Kathryn O'Donnell, Karen I. Zeller, Jung-whan Kim, Jason Yustein, Linda A. Lee and Chi V. Dang. Myc stimulates mitochondrial biogenesis and nuclear encoded mitochondrial genes, Mol. Cell. Biol. 25: 6225-6234 (2005)
  14. Jung-whan Kim and Chi V. Dang. Multifaceted Roles of Glycolytic Enzymes. Trends in Biochemical Sciences, 30:142-150 (2005)
  15. Seung-Hoon Lee, Jung-whan Kim, Sun-Hee Oh, Yong-Jin Kim, Seung-Bae Rho, Kyungsook Park, Kui-Lea Park and Je-ho Lee. IFN-gamma/IRF-1-induced p27 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Letters,579:1027-1033 (2005)
  16. Jung-whan Kim, Karen I. Zeller, Yunyue Wang, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O'Donnell, and Chi V. Dang. Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays. Mol. Cell. Biol. 24:5923-5936 (2004)
  17. Jung-whan Kim, Christopher W. Wong, Jeffery D. Goldsmith, C.Song, Weili Fu, Mary-Beth Allion, Meenhard Herlyn, Abu B. Al-Mehdi, and Ruth J. Muschel. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Letters, 213:203-212 (2004)
  18. Seung-Hoon Lee, Jung-whan Kim, Yongsuk Cho, Sunhee Oh, Hanwoong Lee, Wei Zhang and Jeho Lee. Interferon Regulatory Factor 1 (IRF-1) Is a Mediator for Interferon-g-induced Attenuation of Telomerase Activity and Human Telomerase Reverse Transcriptase (hTERT) Expression. Oncogene,22:381-391 (2003)
  19. Seung-Hoon Lee, Wei Zhang, Jung-joo Choi, Yong-Suk Cho, Sun-Hee Lee, Jung-whan Kim, Limei Hu, Jie Xu, Jinsong Liu and Joho Lee. Overexpression of the Thymosin beta-10 Gene in Human Ovarian Cancer Cells Disrupts F-Actin Stress Fiber and Leads to Apoptosis. Oncogene,20:6700-6706 (2001)
  20. Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001)

Book Chapters

  1. Chi V. Dang, Ping Gao and Jung-whan Kim. The Warburg effect and tumor metabolism. Encyclopedia of CANCER In press
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